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NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that facilitates the nuclear import of cytosolic cargoes by utilizing the nuclear-localized bromodomain-containing protein 4 (BRD4) as a carrier for co-import and subsequent nuclear entrapment [1].

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
| Description | NICE-01 (AP1867-PEG2-JQ1; AP-PEG2-JQ1) is a bifunctional compound that facilitates the nuclear import of cytosolic cargoes by utilizing the nuclear-localized bromodomain-containing protein 4 (BRD4) as a carrier for co-import and subsequent nuclear entrapment [1]. |
| Synonyms | AP-PEG2-JQ1, AP1867-PEG2-JQ1 |
| Molecular Weight | 1206.84 |
| Formula | C63H76ClN7O13S |
| Cas No. | 2982819-94-1 |
| Smiles | CC=1C2=C(N3C([C@H](CC(NCCOCCOCCNC(COC4=CC([C@H](OC(=O)[C@H]5N(C([C@@H](CC)C6=CC(OC)=C(OC)C(OC)=C6)=O)CCCC5)CCC7=CC(OC)=C(OC)C=C7)=CC=C4)=O)=O)N=C2C8=CC=C(Cl)C=C8)=NN=C3C)SC1C |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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