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TNF-α-IN-2

🥰Excellent
Catalog No. T36097Cas No. 2074702-04-6
Alias TNFα-IN-2

TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.

TNF-α-IN-2

TNF-α-IN-2

🥰Excellent
Purity: 99.92%
Catalog No. T36097Alias TNFα-IN-2Cas No. 2074702-04-6
TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.
Pack SizePriceAvailabilityQuantity
1 mg$263In Stock
5 mg$645In Stock
10 mg$987In Stock
25 mg$1,990In Stock
50 mg$3,190In Stock
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Purity:99.92%
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Product Introduction

Bioactivity
Description
TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.
Targets&IC50
CD40:25 nM
In vitro
TNF-α-IN-2 can inhibit the expression of E-selectin induced by soluble TNFα in HUVECs cells with an IC50 value of 30 nM. [1]
In vivo
Methods: TNF-α-IN-2 (5-25 mg/kg, oral) was used to treat mice 1 hour before TNF stimulation, and the changes in IL-6 levels in mice were measured.
Results: TNF-α-IN-2 can inhibit TNF-induced IL-6 in mice. [1]
AliasTNFα-IN-2
Chemical Properties
Molecular Weight494.92
FormulaC25H21ClF2N6O
Cas No.2074702-04-6
SmilesN([C@H](C)C1=CC(C#N)=CC=C1F)C=2C3=C(C=C(F)C(=N3)C=4C=NC(C(C)(C)O)=NC4)N=C(C)C2Cl
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (161.64 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0205 mL10.1026 mL20.2053 mL101.0264 mL
5 mM0.4041 mL2.0205 mL4.0411 mL20.2053 mL
10 mM0.2021 mL1.0103 mL2.0205 mL10.1026 mL
20 mM0.1010 mL0.5051 mL1.0103 mL5.0513 mL
50 mM0.0404 mL0.2021 mL0.4041 mL2.0205 mL
100 mM0.0202 mL0.1010 mL0.2021 mL1.0103 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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