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TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $263 | In Stock | |
5 mg | $645 | In Stock | |
10 mg | $987 | In Stock | |
25 mg | $1,990 | In Stock | |
50 mg | $3,190 | In Stock |
Description | TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis. |
Targets&IC50 | CD40:25 nM |
In vitro | TNF-α-IN-2 can inhibit the expression of E-selectin induced by soluble TNFα in HUVECs cells with an IC50 value of 30 nM. [1] |
In vivo | Methods: TNF-α-IN-2 (5-25 mg/kg, oral) was used to treat mice 1 hour before TNF stimulation, and the changes in IL-6 levels in mice were measured. Results: TNF-α-IN-2 can inhibit TNF-induced IL-6 in mice. [1] |
Alias | TNFα-IN-2 |
Molecular Weight | 494.92 |
Formula | C25H21ClF2N6O |
Cas No. | 2074702-04-6 |
Smiles | N([C@H](C)C1=CC(C#N)=CC=C1F)C=2C3=C(C=C(F)C(=N3)C=4C=NC(C(C)(C)O)=NC4)N=C(C)C2Cl |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (161.64 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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