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TNF-α-IN-2

Name: TNF-α-IN-2
Brand: TargetMol
SKU: T36097
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36097Cas No. 2074702-04-6

Alias TNFα-IN-2

TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.

TNF-α-IN-2

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Purity: 99.92%

Catalog No. T36097Alias TNFα-IN-2Cas No. 2074702-04-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$263	-	In Stock
5 mg	$645	-	In Stock
10 mg	$969	-	In Stock
25 mg	$1,730	-	In Stock
50 mg	$2,430	-	In Stock
1 mL x 10 mM (in DMSO)	$688	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Appearance:Solid

Color:Pink

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.
Targets&IC50	CD40:25 nM
In vitro	TNF-α-IN-2 can inhibit the expression of E-selectin induced by soluble TNFα in HUVECs cells with an IC50 value of 30 nM. [1]
In vivo	Methods: TNF-α-IN-2 (5-25 mg/kg, oral) was used to treat mice 1 hour before TNF stimulation, and the changes in IL-6 levels in mice were measured. Results: TNF-α-IN-2 can inhibit TNF-induced IL-6 in mice. [1]
Synonyms	TNFα-IN-2

Chemical Properties

Molecular Weight	494.92
Formula	C₂₅H₂₁ClF₂N₆O
Cas No.	2074702-04-6
Smiles	N([C@H](C)C1=CC(C#N)=CC=C1F)C=2C3=C(C=C(F)C(=N3)C=4C=NC(C(C)(C)O)=NC4)N=C(C)C2Cl

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (161.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0205 mL	10.1026 mL	20.2053 mL	101.0264 mL
5 mM	0.4041 mL	2.0205 mL	4.0411 mL	20.2053 mL
10 mM	0.2021 mL	1.0103 mL	2.0205 mL	10.1026 mL
20 mM	0.1010 mL	0.5051 mL	1.0103 mL	5.0513 mL
50 mM	0.0404 mL	0.2021 mL	0.4041 mL	2.0205 mL
100 mM	0.0202 mL	0.1010 mL	0.2021 mL	1.0103 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc