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TNF-α-IN-2

Name: TNF-α-IN-2
Brand: TargetMol
SKU: T36097
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36097Cas No. 2074702-04-6

Alias TNFα-IN-2

TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.

TNF-α-IN-2

🥰Excellent

Purity: 99.92%

Catalog No. T36097Alias TNFα-IN-2Cas No. 2074702-04-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$263	-	In Stock
5 mg	$645	-	In Stock
10 mg	$987	-	In Stock
25 mg	$1,990	-	In Stock
50 mg	$3,190	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.92%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TNF-α-IN-2 is an effective and orally active TNFα inhibitor that distorts the TNFα trimer upon binding, causing abnormal signal transduction when it binds to TNFR1, and can be used to study rheumatoid arthritis.
Targets&IC50	CD40:25 nM
In vitro	TNF-α-IN-2 can inhibit the expression of E-selectin induced by soluble TNFα in HUVECs cells with an IC50 value of 30 nM. [1]
In vivo	Methods: TNF-α-IN-2 (5-25 mg/kg, oral) was used to treat mice 1 hour before TNF stimulation, and the changes in IL-6 levels in mice were measured. Results: TNF-α-IN-2 can inhibit TNF-induced IL-6 in mice. [1]
Synonyms	TNFα-IN-2

Chemical Properties

Molecular Weight	494.92
Formula	C₂₅H₂₁ClF₂N₆O
Cas No.	2074702-04-6
Smiles	N([C@H](C)C1=CC(C#N)=CC=C1F)C=2C3=C(C=C(F)C(=N3)C=4C=NC(C(C)(C)O)=NC4)N=C(C)C2Cl
Color	Pink
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (161.64 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.67 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0205 mL	10.1026 mL	20.2053 mL	101.0264 mL
5 mM	0.4041 mL	2.0205 mL	4.0411 mL	20.2053 mL
10 mM	0.2021 mL	1.0103 mL	2.0205 mL	10.1026 mL
20 mM	0.1010 mL	0.5051 mL	1.0103 mL	5.0513 mL
50 mM	0.0404 mL	0.2021 mL	0.4041 mL	2.0205 mL
100 mM	0.0202 mL	0.1010 mL	0.2021 mL	1.0103 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc