Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment. Exhibiting potent antitumor properties, it inhibits HCT-116 cell growth with an IC50 of 0.49 μM. This compound also facilitates GPX4 degradation, leading to lipid ROS accumulation, thereby inducing ferroptosis [1].
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Description | GPX4-IN-7 (Compound 31), an indirubin derivative, serves as a ferroptosis inducer in colon cancer treatment. Exhibiting potent antitumor properties, it inhibits HCT-116 cell growth with an IC50 of 0.49 μM. This compound also facilitates GPX4 degradation, leading to lipid ROS accumulation, thereby inducing ferroptosis [1]. |
Molecular Weight | 478.93 |
Formula | C25H23ClN4O4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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GPX4-IN-7 Apoptosis Ferroptosis inhibitor inhibit