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Amino-PEG3-C2-Azido, a polyethylene glycol (PEG)-based linker, is utilized in synthesizing iRucaparib-TP3, a PARP1 degrader [1].
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Description | Amino-PEG3-C2-Azido, a polyethylene glycol (PEG)-based linker, is utilized in synthesizing iRucaparib-TP3, a PARP1 degrader [1]. |
In vitro | Pomalidomide, a CRBN ligand and recognized immunomodulatory imide drug (IMiD), is conjugated with Rucaparib via a tri(ethylene glycol) (PEG3) linker, resulting in a compound termed iRucaparib-TP3 (IMiD-Rucaparib with a triazole-PEG3 linker). This compound facilitates the degradation of PARP1[1]. |
Molecular Weight | 218.2535 |
Formula | C8H18N4O3 |
Cas No. | 134179-38-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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