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Bomedemstat

🥰Excellent
Catalog No. T9634Cas No. 1990504-34-1
Alias IMG-7289, IMG7289

Bomedemstat (IMG-7289), an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor, shows activity in mouse myeloproliferative neoplasm (MPN) models. This compound exhibits antineoplastic effects and can be used for acute myeloid leukemia (AML) and myelofibrosis (MF) research.

Bomedemstat

Bomedemstat

🥰Excellent
Catalog No. T9634Alias IMG-7289, IMG7289Cas No. 1990504-34-1
Bomedemstat (IMG-7289), an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor, shows activity in mouse myeloproliferative neoplasm (MPN) models. This compound exhibits antineoplastic effects and can be used for acute myeloid leukemia (AML) and myelofibrosis (MF) research.
Pack SizePriceAvailabilityQuantity
1 mg$67In Stock
5 mg$162In Stock
10 mg$243In Stock
25 mg$411In Stock
50 mg$598In Stock
100 mg$848In Stock
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Product Introduction

Bioactivity
Description
Bomedemstat (IMG-7289), an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor, shows activity in mouse myeloproliferative neoplasm (MPN) models. This compound exhibits antineoplastic effects and can be used for acute myeloid leukemia (AML) and myelofibrosis (MF) research.
In vitro
Bomedemstat (50 nM-1 μM, 96 hours) treatment of SET-2 cells increases survival and induces apoptosis via BCL-XL and PUMA in a TP53-dependent manner, leading to cell cycle arrest. [1]
In vivo
Once-daily treatment with IMG-7289 normalized or improved blood cell counts, reduced spleen volumes, restored normal splenic architecture, and reduced bone marrow fibrosis. Most importantly, LSD1 inhibition lowered mutant allele burden and improved survival [1]. Animal Model: Mx1cre-Jak2 V617F mice [1] Dosage: 45 mg/kg Administration: Administered daily by oral gavage for either 14, 42, or 56 consecutive days Result: In this Mx-Jak2V617F model of myeloproliferative neoplasm (MPN), mice developed severe splenomegaly (up to 10-fold increase in spleen weight). Splenic architecture was completely destroyed, eliminating demarcation of the white and red pulp. Treatment significantly reduced splenomegaly with a few treated mice normalizing their spleen weight. Remarkably, the 56-day course led to partial restoration of lymph follicles and spleen architecture by histological examination.
SynonymsIMG-7289, IMG7289
Chemical Properties
Molecular Weight519.61
FormulaC28H34FN7O2
Cas No.1990504-34-1
SmilesN(CCC[C@@H](C(=O)N1CCN(C)CC1)NC(=O)C2=CC=C(C=C2)N3C=CN=N3)[C@H]4[C@@H](C4)C5=CC=C(F)C=C5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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