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EGFR Peptide (human, mouse) (myristoylated) TFA

Name: EGFR Peptide (human, mouse) (myristoylated) TFA
Brand: TargetMol
SKU: T83692
Rating: 4.5 (1 reviews)

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Catalog No. T83692

Alias N-myristoyl-RKRTLRRL, Myr-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH, Epidermal Growth Factor Receptor Peptide

EGFR peptide (myristoylated), a synthetic peptide inhibitor of PKC (IC50 = 5 µM), corresponds to the intracellular region's amino acid sequence of EGFR. It effectively reverses doxorubicin resistance in UV-2237M (UV-2237M-ADRR) fibrosarcoma cells at a concentration of 1 µM.

EGFR Peptide (human, mouse) (myristoylated) TFA

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Catalog No. T83692Alias N-myristoyl-RKRTLRRL, Myr-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH, Epidermal Growth Factor Receptor Peptide

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$105	Inquiry	Inquiry
10 mg	$196	Inquiry	Inquiry
50 mg	$790	Inquiry	Inquiry
100 mg	$1,260	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	EGFR peptide (myristoylated), a synthetic peptide inhibitor of PKC (IC50 = 5 µM), corresponds to the intracellular region's amino acid sequence of EGFR. It effectively reverses doxorubicin resistance in UV-2237M (UV-2237M-ADRR) fibrosarcoma cells at a concentration of 1 µM.
Synonyms	N-myristoyl-RKRTLRRL, Myr-Arg-Lys-Arg-Thr-Leu-Arg-Arg-Leu-OH, Epidermal Growth Factor Receptor Peptide

Chemical Properties

Molecular Weight	1308.71
Formula	C₆₀H₁₁₇N₂₁O₁₁.XCF₃COOH
Smiles	CC(C)C[C@@H](C(O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
Sequence	Ac-Tyr(PO3H2)-xiIle-Asn-Gln-Ser-Val-NH2
Sequence Short	XXNQSV

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS pH 7.2: 2 mg/mL (1.53 mM), Sonication is recommended.

DMSO: 10 mg/mL (7.64 mM), Sonication is recommended.

DMF: 10 mg/mL (7.64 mM), Sonication is recommended.

Solution Preparation Table

PBS pH 7.2/DMSO/DMF

	1mg	5mg	10mg	50mg
1 mM	0.7641 mL	3.8206 mL	7.6411 mL	38.2056 mL

DMSO/DMF

	1mg	5mg	10mg	50mg
5 mM	0.1528 mL	0.7641 mL	1.5282 mL	7.6411 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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