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Zamerovimab

Catalog No. T80589 CAS 2419087-87-7

Synonyms: SYN023, CTB011

Zamerovimab (CTB011; SYN023), a composite of human monoclonal antibodies CTB011 and CTB012, targets distinct, non-overlapping epitopes on the rabies virus (RABV) glycoprotein, with CTB011 specifically binding to antigenic site III. This compound is applicable in rabies research [1].

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Zamerovimab

Zamerovimab, CAS 2419087-87-7

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Description	Zamerovimab (CTB011; SYN023), a composite of human monoclonal antibodies CTB011 and CTB012, targets distinct, non-overlapping epitopes on the rabies virus (RABV) glycoprotein, with CTB011 specifically binding to antigenic site III. This compound is applicable in rabies research [1].
In vitro	Zamerovimab (CTB011; SYN023) at concentrations ranging from 0.001 to 100 μg/mL for 4 hours induces dose-dependent cytotoxicity in BSR cells infected with CVS, facilitating viral clearance. This cytotoxic effect is also shown to correlate with the cell specificity for expressing the G protein, which are targeted by CTB011 [1].
In vivo	Zamerovimab (CTB011; SYN023), administered via intramuscular injection into the right gastrocnemius at doses ranging from 0.03 to 1.0 mg/kg for a single dose on day 35, was shown to increase the survival rate of Syrian hamsters infected with the rabies virus RABV BD06 in a dose-dependent manner. At doses of 0.03, 0.1, 0.3, and 1.0 mg/kg, the survival rates were 58%, 83%, 100%, and 100%, respectively [1].

Synonyms	SYN023, CTB011
Molecular Weight	N/A
CAS No.	2419087-87-7

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Zamerovimab 2419087-87-7 SYN023 CTB011 inhibitor inhibit

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