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IL-31RA Protein, Human, Recombinant (aa 20-519, His)
(Synonyms: ZcytoR17, PRO21384, IL-31R-α, IL-31R-alpha, IL-31RA, GPL, Gp130-like receptor, GLM-RMGC125346, GLM-R, CRL3Glmr, CRL3) Copy Product InfoSynonyms: ZcytoR17, PRO21384, IL-31R-α, IL-31R-alpha, IL-31RA, GPL, Gp130-like receptor, GLM-RMGC125346, GLM-R, CRL3Glmr, CRL3
Catalog No. TMPK-01114 Copy Product Info
Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons. IL-31RA Protein, Human, Recombinant (aa 20-519, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 58.2 kDa and the accession number is Q8NI17-1.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $58 | 7-10 days | 7-10 days | |
| 10 µg | $92 | 7-10 days | 7-10 days | |
| 20 µg | $148 | 7-10 days | 7-10 days | |
| 50 µg | $289 | 7-10 days | 7-10 days | |
| 100 µg | $487 | 7-10 days | 7-10 days | |
| 200 µg | $883 | 7-10 days | 7-10 days | |
| 500 µg | $1,950 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | 1. Immobilized Human IL-31 RA, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-IL-31 RA Antibody, hFc Tag with the EC50 of 6.5ng/ml determined by ELISA (QC Test).
2. Human IL-31, His Tag immobilized on CM5 Chip can bind Human IL-31 RA, His Tag with an affinity constant of 82.4nM as determined in a SPR assay. |
| Description | Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons. IL-31RA Protein, Human, Recombinant (aa 20-519, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 58.2 kDa and the accession number is Q8NI17-1. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | Q8NI17-1 |
| Construction | Ala20-Glu519 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Synonyms | ZcytoR17, PRO21384, IL-31R-α, IL-31R-alpha, IL-31RA, GPL, Gp130-like receptor, GLM-RMGC125346, GLM-R, CRL3Glmr, CRL3 |
| Research Background | Interleukin-31 receptor A (IL-31RA) is a newly identified type I cytokine receptor, that is related to gp130, the common receptor of the interleukin (IL) -6 family cytokines. IL-31RA forms a functional receptor complex for IL-31 together with the beta subunit of oncostatin M receptor (OSMRbeta). OSMRbeta is expressed in a subset of small-sized nociceptive neurons of adult dorsal root ganglia (DRGs).IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons. |
| Molecular Weight | 58.2 kDa (predicted). Due to glycosylation, the protein migrates to 90-116 kDa based on Tris-Bis PAGE result. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: IL-31RA Protein, Human, Recombinant (aa 20-519, His) chemical structure | IL-31RA Protein, Human, Recombinant (aa 20-519, His) molecular weight
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