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Phenazopyridine

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Catalog No. T60260Cas No. 94-78-0

Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections, causing urine to turn orange to red. Phenazopyridine exhibits micromolar-level inhibitory activity against SARM1 and TRPM8.

Phenazopyridine

Phenazopyridine

🥰Excellent
Purity: 99.98%
Catalog No. T60260Cas No. 94-78-0
Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections, causing urine to turn orange to red. Phenazopyridine exhibits micromolar-level inhibitory activity against SARM1 and TRPM8.
Pack SizePriceAvailabilityQuantity
2 mg$35In Stock
5 mg$56In Stock
10 mg$93In Stock
25 mg$155In Stock
50 mg$228In Stock
100 mg$342In Stock
200 mg$497In Stock
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Purity:99.98%
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Product Introduction

Bioactivity
Description
Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections, causing urine to turn orange to red. Phenazopyridine exhibits micromolar-level inhibitory activity against SARM1 and TRPM8.
In vitro
Method:
Human SH-SY5Y cells and mouse N2a cells were treated with Phenazopyridine at concentrations of 10–30 μM for 12 hours.

Result:
Phenazopyridine treatment significantly increased the expression levels of RPS23RG1 mRNA in both cell types.[2]
In vivo
Method:
In APP/PS1 Alzheimer's disease (AD) mice, Phenazopyridine was administered at a dose of 15 mg/kg via intracerebroventricular injection once daily for 2 consecutive weeks.

Result:
Phenazopyridine improved certain AD-related cognitive impairments and pathological features in APP/PS1 mice by promoting the expression of Rps23rg1.[2]
Chemical Properties
Molecular Weight213.24
FormulaC11H11N5
Cas No.94-78-0
SmilesN(=NC1=CC=C(N=C1N)N)C=2C=CC=CC2
ColorOrange
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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