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Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections, causing urine to turn orange to red. Phenazopyridine exhibits micromolar-level inhibitory activity against SARM1 and TRPM8.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $35 | In Stock | |
5 mg | $56 | In Stock | |
10 mg | $93 | In Stock | |
25 mg | $155 | In Stock | |
50 mg | $228 | In Stock | |
100 mg | $342 | In Stock | |
200 mg | $497 | In Stock |
Description | Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections, causing urine to turn orange to red. Phenazopyridine exhibits micromolar-level inhibitory activity against SARM1 and TRPM8. |
In vitro | Method: Human SH-SY5Y cells and mouse N2a cells were treated with Phenazopyridine at concentrations of 10–30 μM for 12 hours. Result: Phenazopyridine treatment significantly increased the expression levels of RPS23RG1 mRNA in both cell types.[2] |
In vivo | Method: In APP/PS1 Alzheimer's disease (AD) mice, Phenazopyridine was administered at a dose of 15 mg/kg via intracerebroventricular injection once daily for 2 consecutive weeks. Result: Phenazopyridine improved certain AD-related cognitive impairments and pathological features in APP/PS1 mice by promoting the expression of Rps23rg1.[2] |
Molecular Weight | 213.24 |
Formula | C11H11N5 |
Cas No. | 94-78-0 |
Smiles | N(=NC1=CC=C(N=C1N)N)C=2C=CC=CC2 |
Color | Orange |
Appearance | Solid |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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