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Phenazopyridine
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Catalog No. T60260Cas No. 94-78-0
Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections, causing urine to turn orange to red. Phenazopyridine exhibits micromolar-level inhibitory activity against SARM1 and TRPM8.
Phenazopyridine
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Purity: 99.98%
Catalog No. T60260Cas No. 94-78-0
Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections, causing urine to turn orange to red. Phenazopyridine exhibits micromolar-level inhibitory activity against SARM1 and TRPM8.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $35 | In Stock | In Stock | |
| 5 mg | $56 | In Stock | In Stock | |
| 10 mg | $93 | In Stock | In Stock | |
| 25 mg | $155 | In Stock | In Stock | |
| 50 mg | $228 | In Stock | In Stock | |
| 100 mg | $342 | - | In Stock | |
| 200 mg | $497 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.98%
Appearance:Solid
Color:Orange
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Phenazopyridine is an orally administered azo dye with local analgesic effects on urinary tract infections, causing urine to turn orange to red. Phenazopyridine exhibits micromolar-level inhibitory activity against SARM1 and TRPM8. |
| In vitro | Method: Human SH-SY5Y cells and mouse N2a cells were treated with Phenazopyridine at concentrations of 10–30 μM for 12 hours. Result: Phenazopyridine treatment significantly increased the expression levels of RPS23RG1 mRNA in both cell types.[2] |
| In vivo | Method: In APP/PS1 Alzheimer's disease (AD) mice, Phenazopyridine was administered at a dose of 15 mg/kg via intracerebroventricular injection once daily for 2 consecutive weeks. Result: Phenazopyridine improved certain AD-related cognitive impairments and pathological features in APP/PS1 mice by promoting the expression of Rps23rg1.[2] |
| Molecular Weight | 213.24 |
| Formula | C11H11N5 |
| Cas No. | 94-78-0 |
| Smiles | N(=NC1=CC=C(N=C1N)N)C=2C=CC=CC2 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 12.5 mg/mL (58.62 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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