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Epitalon (acetate)

Name: Epitalon (acetate)
Brand: TargetMol
SKU: T35993
Rating: 4.5 (1 reviews)

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Catalog No. T35993Cas No. 307297-40-1

Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.

Epitalon (acetate)

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Catalog No. T35993Cas No. 307297-40-1

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$35	Inquiry	Inquiry
50 mg	$173	Inquiry	Inquiry
100 mg	$309	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Epitalon is a synthetic tetrapeptide with anti-aging properties.1,2,3,4 Dietary administration of epitalon (0.00001% w/w) reduces levels of lipid peroxidation products in aged D. melanogaster tissue homogenates.
In vivo	Epitalon (1 μg/animal) delays age-related estrous shutdown and decreases the frequency of bone marrow cell chromosomal aberrations in female mice.2 It decreases spontaneous mammary gland and ovarian tumor development and metastasis in aged female mice.3 Epitalon also stimulates melatonin synthesis and normalizes the circadian rhythm of cortisol secretion in senescent female M. mulatta monkeys.4

Chemical Properties

Molecular Weight	450.40
Formula	C₁₆H₂₆N₄O₁₁
Cas No.	307297-40-1
Smiles	CC(O)=O.C[C@H](N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)NCC(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 5 mg/mL (11.1 mM), Sonication is recommended.

DMSO: 3 mg/mL (6.66 mM), Sonication is recommended.

DMF: 1 mg/mL (2.22 mM), Sonication is recommended.

Solution Preparation Table

DMF/DMSO/PBS (pH 7.2)

	1mg	5mg	10mg	50mg
1 mM	2.2202 mL	11.1012 mL	22.2025 mL	111.0124 mL

DMSO/PBS (pH 7.2)

	1mg	5mg	10mg	50mg
5 mM	0.4440 mL	2.2202 mL	4.4405 mL	22.2025 mL

PBS (pH 7.2)

	1mg	5mg	10mg	50mg
10 mM	0.2220 mL	1.1101 mL	2.2202 mL	11.1012 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Epitalon (acetate)Epitalon