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ATG3 Protein, Human, Recombinant

Catalog No. TMPJ-01354
Synonyms: ATG3, Ubiquitin-like-conjugating enzyme ATG3, APG3, Protein PC3-96, Autophagy-related protein 3, APG3-like, APG3L, hApg3

Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its mouse and rat orthologs. It is widely expressed and has highly levels in heart, skeletal muscle, kidney, liver and placenta. As an E2-like enzyme, involves in autophagy and mitochondrial homeostasis. ATG3 catalyzes the conjugation of ATG8-like proteins to PE which is essential for autophagy. ATG3 also can catalyze the conjugation of ATG12 to itself which palys a role in mitochondrial homeostasis but not in autophagy.

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ATG3 Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 35.00
50 μg 5 days $ 97.00
500 μg 5 days $ 434.00
1 mg 5 days $ 621.00
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Biological Description
Technical Params
Product Properties
Description Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its mouse and rat orthologs. It is widely expressed and has highly levels in heart, skeletal muscle, kidney, liver and placenta. As an E2-like enzyme, involves in autophagy and mitochondrial homeostasis. ATG3 catalyzes the conjugation of ATG8-like proteins to PE which is essential for autophagy. ATG3 also can catalyze the conjugation of ATG12 to itself which palys a role in mitochondrial homeostasis but not in autophagy.
Species Human
Expression System E. coli
Tag C-6His,N-T7 tag
Accession Number Q9NT62
Synonyms ATG3, Ubiquitin-like-conjugating enzyme ATG3, APG3, Protein PC3-96, Autophagy-related protein 3, APG3-like, APG3L, hApg3
Amino Acid Met1-Met314
Construction Recombinant Human Ubiquitin-like-conjugating Enzyme ATG3/ATG3 is produced by our E.coli expression system and the target gene encoding Met1-Met314 is expressed.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 38 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Research Background Ubiquitin-like-conjugating enzyme ATG3 (ATG3), also known as Apg3L and Apg3p, functions as a regulatory component of autophagosome biogenesis necessary for autophagy. ATG3 exhibits 98% aa sequence identity with both its mouse and rat orthologs. It is widely expressed and has highly levels in heart, skeletal muscle, kidney, liver and placenta. As an E2-like enzyme, involves in autophagy and mitochondrial homeostasis. ATG3 catalyzes the conjugation of ATG8-like proteins to PE which is essential for autophagy. ATG3 also can catalyze the conjugation of ATG12 to itself which palys a role in mitochondrial homeostasis but not in autophagy.

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Keywords

ATG3 Protein, Human, Recombinant ATG3 ATG 3 Ubiquitin-like-conjugating enzyme ATG3 APG3 Protein PC3-96 Autophagy-related protein 3 APG-3 APG 3 APG3-like APG3L ATG-3 hApg3 recombinant recombinant-proteins proteins protein

 

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