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15-keto-Prostaglandin E2
😃Good
Catalog No. T78582Cas No. 26441-05-4
Alias 15-keto-PGE2
15-keto-Prostaglandin E2 is an endogenous bioactive metabolite that inhibits STAT3 activation through covalent interaction with the Cys259 residue, while also binding to and stabilizing EP2 and EP4 receptors, thereby exerting inhibitory effects on breast cancer cell growth and tumor progression, activating PPAR-γ signaling, and promoting fungal growth, collectively positioning this lipid mediator as a multifunctional regulator in cancer biology, immunometabolism, and host–pathogen interaction research.
15-keto-Prostaglandin E2
😃Good
Purity: 98.31%
Catalog No. T78582Alias 15-keto-PGE2Cas No. 26441-05-4
15-keto-Prostaglandin E2 is an endogenous bioactive metabolite that inhibits STAT3 activation through covalent interaction with the Cys259 residue, while also binding to and stabilizing EP2 and EP4 receptors, thereby exerting inhibitory effects on breast cancer cell growth and tumor progression, activating PPAR-γ signaling, and promoting fungal growth, collectively positioning this lipid mediator as a multifunctional regulator in cancer biology, immunometabolism, and host–pathogen interaction research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $1,140 | - | In Stock | |
| 5 mg | $3,410 | - | In Stock | |
| 10 mg | $5,120 | - | In Stock | |
| 25 mg | $8,700 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.31%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 15-keto-Prostaglandin E2 is an endogenous bioactive metabolite that inhibits STAT3 activation through covalent interaction with the Cys259 residue, while also binding to and stabilizing EP2 and EP4 receptors, thereby exerting inhibitory effects on breast cancer cell growth and tumor progression, activating PPAR-γ signaling, and promoting fungal growth, collectively positioning this lipid mediator as a multifunctional regulator in cancer biology, immunometabolism, and host–pathogen interaction research. |
| In vivo | In a mouse xenograft model using MDA-MB-231 cells, intraperitoneal (i.p.) injection of 15-keto-Prostaglandin E2 suppressed tumor growth, resulting in reduced tumor volume and weight. This reduction correlates with the downregulation of p-STAT3 and Cyclin D1 levels in the tumor tissues [1]. |
| Synonyms | 15-keto-PGE2 |
| Molecular Weight | 350.45 |
| Formula | C20H30O5 |
| Cas No. | 26441-05-4 |
| Smiles | C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/C(CCCCC)=O)[C@H](O)CC1=O |
| Color | Yellow |
| Appearance | Solid |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (228.28 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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