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N-Acetyl-DL-penicillamine

Catalog No. T38156 CAS 59-53-0

N-Acetyl-DL-penicillamine is a chelating agent.1,2,3It inhibits the binding of methyl mercury to isolated human erythrocytes by 50% and removes 50% of methyl mercury ions from methyl mercury-loaded blood cells when used at a concentration of 1 mM.1,2N-Acetyl-DL-penicillamine (3 mmol/kg per day, p.o.) reduces the biological half-life of mercury and decreases liver, kidney, brain, and blood mercury levels, as well as increases urinary excretion of mercury in a concentration-dependent manner, in mice when administered following injection of methyl mercuric chloride. It decreases mercuric chloride-induced mortality in mice when administered orally at a dose of 1.6 mmol/kg.3N-Acetyl-DL-penicillamine is also an analog of SNAP that does not generate nitric oxide and has been used as a negative control in experiments using SNAP.4,5

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N-Acetyl-DL-penicillamine Chemical Structure

N-Acetyl-DL-penicillamine, CAS 59-53-0

Pack Size	Availability	Price/USD	Quantity
500 mg	35 days	$ 380.00
5 g	35 days	$ 2,510.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	191.248
Formula	C7H13NO3S
CAS No.	59-53-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 30 mg/mL

DMSO:PBS (pH 7.2) (1:7): 0.12 mg/mL

DMSO: 30 mg/mL

Ethanol: 5 mg/mL

References and Literature

1. Aaseth, J.Mobilization of methyl mercury in vivo and in vitro using N-acetyl-DL-penicillamine and other complexing agentsActa Pharm. Toxicol. (Copenh.)39(3)289-301(1976) 2. Aaseth, J., Alexander, J., and Deverill, J.Evaluation of methyl mercury chelating agents using red blood cells and isolated hepatocytesChem. Biol. Interact.36(3)287-297(1981) 3. Nielsen, J.B., and Andersen, O.Effect of four thiol-containing chelators on disposition of orally administered mercuric chlorideHum. Exp. Toxicol.10(6)423-430(1991) 4. Ogura, T., DeGeorge, G., Tatemichi, M., et al.Suppression of anti-microtubule agent-induced apoptosis by nitric oxide: Possible mechanism of a new drug resistanceJpn. J. Cancer Res.89(2)199-205(1998) 5. Takhampunya, R., Padmanabhan, R., and Ubol, S.Antiviral action of nitric oxide on dengue virus type 2 replicationJ. Gen. Virol.87(Pt. 10)3003-3011(2006)

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Keywords

N-Acetyl-DL-penicillamine 59-53-0 NAcetylDLpenicillamine N Acetyl DL penicillamine inhibitor inhibit

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