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CD86 Protein, Human, Recombinant (His), Biotinylated

Catalog No. TMPY-05246
Synonyms: CD28LG2, B70, B7.2, LAB72, CD86 antigen, B7-2

CD86 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P42081-3.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD86 Protein, Human, Recombinant (His), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 306.00
100 μg 5 days $ 726.00
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Biological Description
Technical Params
Product Properties
References and Literature
Description CD86 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.2 kDa and the accession number is P42081-3.
Species Human
Expression System HEK293 Cells
Tag C-His
Accession Number P42081-3
Synonyms CD28LG2, B70, B7.2, LAB72, CD86 antigen, B7-2
Construction The extracellular domain (Met1-His239) of Human B7-2 (NP_008820.2) was fused with a polyhistidine tag at the C-terminus. The purified protein was biotinylated in vitro.
Protein Purity > 95 % as determined by SDS-PAGE.
Molecular Weight 26.2 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing Sterile PBS. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. A recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

References and Literature

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Keywords

CD86 Protein, Human, Recombinant (His), Biotinylated CD28LG2 B-70 LAB-72 B70 LAB 72 B7.2 B 70 LAB72 CD86 antigen B7-2 recombinant recombinant-proteins proteins protein

 

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