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Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab reduces TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used in the study of thyroid-associated eye diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 198.00 | |
5 mg | In stock | $ 578.00 | |
10 mg | In stock | $ 928.00 | |
25 mg | In stock | $ 1,380.00 | |
50 mg | In stock | $ 1,860.00 | |
100 mg | In stock | $ 2,490.00 |
Description | Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab reduces TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used in the study of thyroid-associated eye diseases. |
In vitro | In fibrocytes, Teprotumumab (0-500 μg/mL, 12 h) attenuates the actions of both IGF-1 and TSH. However, the mRNA abundance of IGF-1R and TSHR is unaffected by Teprotumumab after 24 hours[1]. |
Synonyms | R 1507, HZN 001 |
Molecular Weight | N/A |
CAS No. | 1036734-93-6 |
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store at -20°C
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Teprotumumab 1036734-93-6 GPCR/G Protein Tyrosine Kinase/Adaptors TSH Receptor IGF-1R HZN001 R 1507 R-1507 R1507 HZN-001 HZN 001 inhibitor inhibit