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Dehydrocavidine

Catalog No. TN1139 CAS 83218-34-2

Synonyms: Dehydrocorydaline

Dehydrocavidine has antitumor activity, it inhibits MCF-7 cell proliferation by inducing Apoptosis mediated by regulating Bax/BCL-2, activating caspases as well as cleaving PARP.

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Dehydrocavidine, CAS 83218-34-2

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Purity: 98%

Biological Description

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Description

Dehydrocavidine has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP.

In vitro

The complexation behavior of palmatine (P) and Dehydrocorydaline (DHC) alkaloid guest molecules by cucurbit[7]uril (CB7) host have been investigated by means of fluorescence spectra in aqueous phosphate buffer solution (pH 7.2). It is found that each alkaloid exhibits dramatic fluorescence enhancement upon complexation with CB7, and the intensity of the emittance is strong enough to be readily distinguished by the naked eye. Although the two guests possess similar structure, the complex stability constant of P with CB7 is 5.4 times larger than that of DHC.

Synonyms	Dehydrocorydaline
Molecular Weight	348.37
Formula	C21H18NO4
CAS No.	83218-34-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Selective binding and highly sensitive fluorescent sensor of palmatine and dehydrocorydaline alkaloids by cucurbit[7]uril.Org Biomol Chem. 2009 Jul 7;7(13):2699-703.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dehydrocavidine 83218-34-2 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair PARP BCL Dehydrocorydaline Inhibitor inhibitor inhibit

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