LAG-3 Protein, Mouse, Recombinant (hFc)

Name: LAG-3 Protein, Mouse, Recombinant (hFc)
Brand: TargetMol
SKU: TMPY-04611
Rating: 4.5 (1 reviews)

(Synonyms: lymphocyte-activation gene 3, Ly66, LAG-3, CD223) Copy Product Info

Synonyms: lymphocyte-activation gene 3, Ly66, LAG-3, CD223

Catalog No. TMPY-04611 Copy Product Info

LAG-3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 72.1 kDa and the accession number is Q61790.

Pack Size	Price	USA Stock	Global Stock
5 µg	$68	7-10 days	7-10 days
10 µg	$108	7-10 days	7-10 days
20 µg	$178	7-10 days	7-10 days
50 µg	$357	7-10 days	7-10 days
100 µg	$629	7-10 days	7-10 days
200 µg	$1,090	7-10 days	7-10 days
500 µg	$2,700	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	1. Measured by its ability to bind FGL1 Protein, Mouse, Recombinant (His) (Cat#TMPY-05450) in functional ELISA. 2. Immobilized FGL1 Protein, Mouse, Recombinant (His) (Cat#TMPY-05450) at 2 μg/mL (100 μL/well) can bind LAG-3 Protein, Mouse, Recombinant (hFc) (Cat#TMPY-04611), the EC50 is 214.2 ng/mL.
Description	LAG-3 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 72.1 kDa and the accession number is Q61790.
Species	Mouse
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q61790
Construction	A DNA sequence encoding the mouse Lag3 (NP_032505.1) (Met1-Leu442) was expressed with the Fc region of human IgG1 at the C-terminus. Predicted N terminal: Gly 24
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	lymphocyte-activation gene 3, Ly66, LAG-3, CD223
Research Background	LAG3 (Lymphocyte Activating 3) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to the immunoglobulin (Ig) superfamily. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 contains 4 extracellular Ig-like domains and has a negative regulatory function in T cells. It also acts as a new marker of T cell-induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signaling, leading to increased antigen-specific T-cell responses in vivo. Diseases associated with LAG3 include Smoldering Myeloma and Kyphoscoliotic Heart Disease.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint TargetsImmunotherapyTargeted Therapy

Chemical Properties

Molecular Weight

72.1 kDa (predicted)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.