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TDT Protein, Human, Recombinant (His)

Catalog No. TMPJ-00765
Synonyms: Terminal transferase, Terminal deoxynucleotidyltr, DNTT, Terminal deoxynucleotidyltransferase, DNA nucleotidylexotransferase, TDT, Terminal addition enzyme

Terminal deoxynucleotidyl transferase (TdT) is a highly conserved vertebrate enzyme that possesses the unique ability to catalyze the random addition of deoxynucleoside 5'-triphosphates onto the 3'-hydroxyl group of a single-stranded DNA. It plays an important role in the generation of immunoglobin and T-cell receptor diversity. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
TDT Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 154.00
50 μg 5 days $ 465.00
500 μg 5 days $ 2,330.00
1 mg 5 days $ 3,490.00
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Biological Description
Technical Params
Product Properties
Description Terminal deoxynucleotidyl transferase (TdT) is a highly conserved vertebrate enzyme that possesses the unique ability to catalyze the random addition of deoxynucleoside 5'-triphosphates onto the 3'-hydroxyl group of a single-stranded DNA. It plays an important role in the generation of immunoglobin and T-cell receptor diversity. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
Species Human
Expression System E. coli
Tag N-6His
Accession Number P04053
Synonyms Terminal transferase, Terminal deoxynucleotidyltr, DNTT, Terminal deoxynucleotidyltransferase, DNA nucleotidylexotransferase, TDT, Terminal addition enzyme
Amino Acid Met1-Ala509
Construction Recombinant Human DNA Nucleotidylexotransferase is produced by our E.coli expression system and the target gene encoding Met1-Ala509 is expressed with a 6His tag at the N-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 62 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 0.1M KH<sub>2</sub>PO<sub>4</sub>, 200mM KCl, 1mM 2-Mercaptoethanol, 50% Glycerol, pH 7.2.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.
Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.
Research Background Terminal deoxynucleotidyl transferase (TdT) is a highly conserved vertebrate enzyme that possesses the unique ability to catalyze the random addition of deoxynucleoside 5'-triphosphates onto the 3'-hydroxyl group of a single-stranded DNA. It plays an important role in the generation of immunoglobin and T-cell receptor diversity. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.

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Keywords

TDT Protein, Human, Recombinant (His) Terminal transferase Terminal deoxynucleotidyltr DNTT Terminal deoxynucleotidyltransferase DNA nucleotidylexotransferase TDT Terminal addition enzyme recombinant recombinant-proteins proteins protein

 

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