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NF-κB-IN-8
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Catalog No. T74799Cas No. 2924565-59-1
NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2. Additionally, it inhibits ALP activity and is usable in inflammation research, including acute lung injury (ALI) [1].
NF-κB-IN-8
NF-κB-IN-8
Copy Product Info😃Good
Catalog No. T74799Cas No. 2924565-59-1
NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2. Additionally, it inhibits ALP activity and is usable in inflammation research, including acute lung injury (ALI) [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NF-κB-IN-8 is a competitive antagonist of LPS for MD-2 binding, and it impedes the expression of inflammatory factors by engaging MD-2. Additionally, it inhibits ALP activity and is usable in inflammation research, including acute lung injury (ALI) [1]. |
| In vitro | NF-κB-IN-8 (compound L26) at a concentration of 10 μM inhibits 64.30% of ALP activity [1]. Additionally, within a range of 1-10 μM for 24 hours, NF-κB-IN-8 suppresses the expression of IL-6 and TNF-α in RAW 264.7 cells [1]. At concentrations spanning from 0 to 50 μM, NF-κB-IN-8 hinders the binding of LPS to MD-2, as detected by ELISA [1]. At 50 μM, administered overnight, the compound prevents the formation of the LPS/MD-2/TLR4 complex in RAW264.7 cells [1]. |
| In vivo | NF-κB-IN-8 (Compound L26), administered orally at a dose of 5 mg/kg, mitigated LPS-induced acute lung injury in mice [1]. At higher doses of 1000 and 1500 mg/kg, NF-κB-IN-8 demonstrated low toxicity and was deemed safe in mice [1]. In rats, with an administered dose of 0 mg/kg, NF-κB-IN-8 exhibited a half-life (T 1/2) of 4.2 hours and a maximum concentration (C max) of 163.288 μg/L [1]. |
| Molecular Weight | 399.44 |
| Formula | C24H21N3O3 |
| Cas No. | 2924565-59-1 |
| Smiles | #N/A |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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