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DOPAL

Catalog No. T37533 CAS 5707-55-1

DOPAL is an aldehyde product of the oxidative deamination of dopamine by monoamine oxidase.[1] It can be further oxidized to 3,4-dihydroxyphenylacetic acid (DOPAC) by aldehyde dehydrogenase (ALDH) and, to a lesser extent reduced to 3,4-dihydroxyphenyl ethanol (DOPET). DOPAL is toxic to neurons.[2],[3] It can also oligomerize and precipitate α-synuclein, an event associated with Parkinson's disease.[2] Mice lacking cytosolic and mitochondrial forms of ALDH display increased levels of DOPAL as well as neurodegeneration and motor dysfunction characteristic of Parkinson’s disease.[4]

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DOPAL, CAS 5707-55-1

Pack Size	Availability	Price/USD	Quantity
5 mg	35 days	$ 118.00
10 mg	35 days	$ 220.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	152.15
Formula	C8H8O3
CAS No.	5707-55-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 15 mg/mL

DMSO: 10 mg/mL

DMF: 15 mg/mL

References and Literature

1. Jinsmaa, Y., Florang, V.R., Rees, J.N., et al. Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate. Chemical Research in Toxicology 22(5), 835-841 (2009). 2. Goldstein, D.S., Sullivan, P., Holmes, C., et al. Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson’s disease. Journal of Neurochemistry 126(5), 591-603 (2013). 3. Panneton, W.M., Kumar, V.B., Gan, Q., et al. The neurotoxicity of DOPAL: Behavioral and stereological evidence for its role in Parkinson disease pathogenesis. PLoS One 5(12), e15251 (2010). 4. Wey, M.C.Y., Fernandez, E., Martinez, P.A., et al. Neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases: implications for Parkinson’s disease. PLoS One 7(2), e31522 (2012).

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Keywords

DOPAL 5707-55-1 inhibitor inhibit

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