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S-F24

Catalog No. T78914 CAS 2946669-78-7

S-F24 is a broad-spectrum antifungal agent that demonstrates potent inhibition of CYP3A4, with an IC50 of 0.4 μM. It exhibits a favorable safety profile, characterized by high selectivity, minimal hemolytic effects, and a reduced propensity for resistance development. S-F24 is useful for fungal infection research [1].

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S-F24, CAS 2946669-78-7

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	S-F24 is a broad-spectrum antifungal agent that demonstrates potent inhibition of CYP3A4, with an IC50 of 0.4 μM. It exhibits a favorable safety profile, characterized by high selectivity, minimal hemolytic effects, and a reduced propensity for resistance development. S-F24 is useful for fungal infection research [1].
In vitro	S-F24 exhibits low cytotoxicity towards mammalian cells at concentrations of 10-30 μM over 48 hours [1]. Additionally, an 8-fold increase in the MIC80 value against C. albicans SC5314 was observed when treated with S-F24 at 0.002 μg/mL over 20 passages [1]. Moreover, S-F24 at a concentration of 0.004 μg/mL for 16 hours inhibited ergosterol synthesis in C. albicans SC5314 by 92.03% [1].
In vivo	S-F24 (1.5 mg/kg, i.p., once daily for 5 days) was extensively used to treat invasive fungal infections caused by C. albicans SC5314, A. fumigatus CGMCC3.7795, and resistant C. albicans 24D in female IRC mice [1]. Additionally, S-F24 at dosages of 0.5 and 1 mg/kg, administered intraperitoneally once daily for 5 days, was highly effective in inhibiting C. albicans SC5314 skin infections in female IRC mice [1].

Molecular Weight	545.42
Formula	C25H27BrF2N6O
CAS No.	2946669-78-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

S-F24 2946669-78-7 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.