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S-F24

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Catalog No. T78914Cas No. 2946669-78-7

S-F24 is a broad-spectrum antifungal agent that demonstrates potent inhibition of CYP3A4, with an IC50 of 0.4 μM. It exhibits a favorable safety profile, characterized by high selectivity, minimal hemolytic effects, and a reduced propensity for resistance development. S-F24 is useful for fungal infection research [1].

S-F24

S-F24

😃Good
Catalog No. T78914Cas No. 2946669-78-7
S-F24 is a broad-spectrum antifungal agent that demonstrates potent inhibition of CYP3A4, with an IC50 of 0.4 μM. It exhibits a favorable safety profile, characterized by high selectivity, minimal hemolytic effects, and a reduced propensity for resistance development. S-F24 is useful for fungal infection research [1].
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$1,5206-8 weeks6-8 weeks
50 mg$1,9806-8 weeks6-8 weeks
100 mg$2,5006-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
S-F24 is a broad-spectrum antifungal agent that demonstrates potent inhibition of CYP3A4, with an IC50 of 0.4 μM. It exhibits a favorable safety profile, characterized by high selectivity, minimal hemolytic effects, and a reduced propensity for resistance development. S-F24 is useful for fungal infection research [1].
In vitro
S-F24 exhibits low cytotoxicity towards mammalian cells at concentrations of 10-30 μM over 48 hours [1]. Additionally, an 8-fold increase in the MIC80 value against C. albicans SC5314 was observed when treated with S-F24 at 0.002 μg/mL over 20 passages [1]. Moreover, S-F24 at a concentration of 0.004 μg/mL for 16 hours inhibited ergosterol synthesis in C. albicans SC5314 by 92.03% [1].
In vivo
S-F24 (1.5 mg/kg, i.p., once daily for 5 days) was extensively used to treat invasive fungal infections caused by C. albicans SC5314, A. fumigatus CGMCC3.7795, and resistant C. albicans 24D in female IRC mice [1]. Additionally, S-F24 at dosages of 0.5 and 1 mg/kg, administered intraperitoneally once daily for 5 days, was highly effective in inhibiting C. albicans SC5314 skin infections in female IRC mice [1].
Chemical Properties
Molecular Weight545.42
FormulaC25H27BrF2N6O
Cas No.2946669-78-7
Smiles[C@@](CN1CCN(CCN2C=3C(C=C2)=CC(Br)=CC3)CC1)(CN4C=NC=N4)(O)C5=C(F)C=C(F)C=C5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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