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IL-18 Protein, Human, Recombinant (His)

Catalog No. TMPJ-00070
Synonyms: GIF, IL-1 γ, Iboctadekin, Interleukin-18, Interferon γ-inducing factor, MGC12320, IL-1 gamma, Interleukin-1 gamma, IL-1g, IFN-gamma-inducing factor, Interleukin-1 γ, IL1F4, IFN-γ-inducing factor, IL-18, Interferon gamma-inducing factor

Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
IL-18 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 129.00
50 μg 5 days $ 390.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number Q14116
Synonyms GIF, IL-1 γ, Iboctadekin, Interleukin-18, Interferon γ-inducing factor, MGC12320, IL-1 gamma, Interleukin-1 gamma, IL-1g, IFN-gamma-inducing factor, Interleukin-1 γ, IL1F4, IFN-γ-inducing factor, IL-18, Interferon gamma-inducing factor
Amino Acid Tyr37-Asp193
Construction Recombinant Human Interleukin-18 is produced by our Mammalian expression system and the target gene encoding Tyr37-Asp193 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 16 KDa, reducing conditions
Endotoxin Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB，150mM NaCl，pH7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon-γ (IFN-γ) or type II interferon that plays an important role in activating the macrophages or other cells.

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Keywords

IL-18 Protein, Human, Recombinant (His) MGC-12320 MGC 12320 GIF IL-1 γ IL 18 Iboctadekin Interleukin-18 Interferon γ-inducing factor MGC12320 IL-1 gamma Interleukin-1 gamma IL-1g IFN-gamma-inducing factor Interleukin-1 γ IL1F4 IFN-γ-inducing factor IL18 IL-18 Interferon gamma-inducing factor recombinant recombinant-proteins proteins protein

 

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