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PIP-199

Name: PIP-199
Brand: TargetMol
SKU: T9126
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9126Cas No. 622795-76-0

Alias PIP199, PIP 199

PIP-199 is a selective inhibitor of the interaction between the RMI core complex and MM2 within the RecQ-mediated genome instability pathway, with an IC50 value of 36 μM, PIP-199 is employed in DNA damage response research to sensitize resistant tumors to DNA crosslinking chemotherapeutic agents and to study genome stability mechanisms.

PIP-199

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Catalog No. T9126Alias PIP199, PIP 199Cas No. 622795-76-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$198	-	In Stock
10 mg	$347	-	In Stock
25 mg	$577	-	In Stock
50 mg	$823	-	In Stock
100 mg	$1,090	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	PIP-199 is a selective inhibitor of the interaction between the RMI core complex and MM2 within the RecQ-mediated genome instability pathway, with an IC50 value of 36 μM, PIP-199 is employed in DNA damage response research to sensitize resistant tumors to DNA crosslinking chemotherapeutic agents and to study genome stability mechanisms.
In vitro	In fluorescence polarization assays, PIP-199 inhibited the interaction between the RMI core complex and the MM2 motif of FANCM with an IC50 of 36 μM [1].
Synonyms	PIP199, PIP 199

Chemical Properties

Molecular Weight	456.54
Formula	C₂₇H₂₈N₄O₃
Cas No.	622795-76-0
Smiles	O=C(OCC)N1CCN(CC1)C(C2=NC=CC=C2)C=3C=4C=CC=CC4N(O)C3C=5C=CC=CC5
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (70.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1904 mL	10.9519 mL	21.9039 mL	109.5194 mL
5 mM	0.4381 mL	2.1904 mL	4.3808 mL	21.9039 mL
10 mM	0.2190 mL	1.0952 mL	2.1904 mL	10.9519 mL
20 mM	0.1095 mL	0.5476 mL	1.0952 mL	5.4760 mL
50 mM	0.0438 mL	0.2190 mL	0.4381 mL	2.1904 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

PIP-199