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PIP-199
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Catalog No. T9126Cas No. 622795-76-0
Alias PIP199, PIP 199
PIP-199 is a selective inhibitor of the interaction between the RMI core complex and MM2 within the RecQ-mediated genome instability pathway, with an IC50 value of 36 μM, PIP-199 is employed in DNA damage response research to sensitize resistant tumors to DNA crosslinking chemotherapeutic agents and to study genome stability mechanisms.
PIP-199
😃Good
Catalog No. T9126Alias PIP199, PIP 199Cas No. 622795-76-0
PIP-199 is a selective inhibitor of the interaction between the RMI core complex and MM2 within the RecQ-mediated genome instability pathway, with an IC50 value of 36 μM, PIP-199 is employed in DNA damage response research to sensitize resistant tumors to DNA crosslinking chemotherapeutic agents and to study genome stability mechanisms.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | - | In Stock | |
| 5 mg | $198 | - | In Stock | |
| 10 mg | $347 | - | In Stock | |
| 25 mg | $577 | - | In Stock | |
| 50 mg | $823 | - | In Stock | |
| 100 mg | $1,090 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | PIP-199 is a selective inhibitor of the interaction between the RMI core complex and MM2 within the RecQ-mediated genome instability pathway, with an IC50 value of 36 μM, PIP-199 is employed in DNA damage response research to sensitize resistant tumors to DNA crosslinking chemotherapeutic agents and to study genome stability mechanisms. |
| In vitro | MM2, a peptide, serves as the binding site for the RMI complex on the Fanconi anemia complementation group M protein (FANCM) [1]. It plays a crucial role in activating the Fanconi anemia (FA) DNA repair pathway, which tumors commonly exploit to develop resistance to DNA crosslinking chemotherapies [1]. Effective operation of the FA pathway hinges on the interaction between FANCM and the RMI complex, with mutations impairing this interaction rendering cells more susceptible to DNA crosslinking agents [1]. |
| Synonyms | PIP199, PIP 199 |
| Molecular Weight | 456.54 |
| Formula | C27H28N4O3 |
| Cas No. | 622795-76-0 |
| Smiles | O=C(OCC)N1CCN(CC1)C(C2=NC=CC=C2)C=3C=4C=CC=CC4N(O)C3C=5C=CC=CC5 |
| Relative Density. | no data available |
| Color | Yellow |
| Appearance | Solid |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 32 mg/mL (70.09 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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