Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative. AV-153 free base is an antimutagenic with anti-cancer activity. AV-153 free base interacts with cytosine and thymine and has an influence on poly(ADP)ribosylation. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro [1] [2] [3].
Description | AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative. AV-153 free base is an antimutagenic with anti-cancer activity. AV-153 free base interacts with cytosine and thymine and has an influence on poly(ADP)ribosylation. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro [1] [2] [3]. |
In vitro | AV-153 free base demonstrates inhibitory concentration values (IC50s) of 14.9 mM and 10.3 mM for Raji and HL-60 cells, respectively [1]. Furthermore, it significantly decreases the occurrence of DNA single-strand breaks (SSBs) in peripheral blood lymphocytes and HL-60 cells by 13–67% when applied in concentrations ranging from 1 nM to 10 μM over a duration of 3 hours [1]. |
Molecular Weight | 297.3 |
Formula | C14H19NO6 |
CAS No. | 19350-66-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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AV-153 free base 19350-66-4 inhibitor inhibit