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2,4,5-Trimethoxybenzoic acid

Name: 2,4,5-Trimethoxybenzoic acid
Brand: TargetMol
SKU: T60256
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60256Cas No. 490-64-2

Alias Asaronic acid

2,4,5-Trimethoxybenzoic acid (Asaronic acid) is a natural product that inhibits M1 macrophage phenotype-induced inflammatory responses and suppresses TLR4/IL-6-mediated activation of NF-κB and JAK-STAT signaling pathways.

2,4,5-Trimethoxybenzoic acid

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Purity: 99.97%

Catalog No. T60256Alias Asaronic acidCas No. 490-64-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$30	-	In Stock
1 g	$39	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.97%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	2,4,5-Trimethoxybenzoic acid (Asaronic acid) is a natural product that inhibits M1 macrophage phenotype-induced inflammatory responses and suppresses TLR4/IL-6-mediated activation of NF-κB and JAK-STAT signaling pathways.
In vitro	2,4,5-Trimethoxybenzoic acid (0-20 μg/mL, 24-72 hours) can inhibit LPS-induced IL-6 and MCP-1 secretion in J774A.1 macrophages, and reduce the expression levels of TLR4, CD36, and CD68 [1]. 2,4,5-Trimethoxybenzoic acid (0-20 μg/mL, 48 hours) not only suppresses high glucose-induced expression of HIF-1α, VEGF, TLR4, iNOS, and IL-6 in J774A.1 macrophages but also promotes the expression of anti-inflammatory factors Arg-1 and IL-10 [1].
Synonyms	Asaronic acid

Chemical Properties

Molecular Weight	212.2
Formula	C₁₀H₁₂O₅
Cas No.	490-64-2
Smiles	O=C(O)C1=CC(OC)=C(OC)C=C1OC
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (377 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7125 mL	23.5627 mL	47.1254 mL	235.6268 mL
5 mM	0.9425 mL	4.7125 mL	9.4251 mL	47.1254 mL
10 mM	0.4713 mL	2.3563 mL	4.7125 mL	23.5627 mL
20 mM	0.2356 mL	1.1781 mL	2.3563 mL	11.7813 mL
50 mM	0.0943 mL	0.4713 mL	0.9425 mL	4.7125 mL
100 mM	0.0471 mL	0.2356 mL	0.4713 mL	2.3563 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc