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2,4,5-Trimethoxybenzoic acid

Name: 2,4,5-Trimethoxybenzoic acid
Brand: TargetMol
SKU: T60256
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60256Cas No. 490-64-2

Alias Asaronic acid

2,4,5-Trimethoxybenzoic acid (Asaronic acid) is a natural product that inhibits M1 macrophage phenotype-induced inflammatory responses and suppresses TLR4/IL-6-mediated activation of NF-κB and JAK-STAT signaling pathways.

2,4,5-Trimethoxybenzoic acid

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Purity: 99.97%

Catalog No. T60256Alias Asaronic acidCas No. 490-64-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.97%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	2,4,5-Trimethoxybenzoic acid (Asaronic acid) is a natural product that inhibits M1 macrophage phenotype-induced inflammatory responses and suppresses TLR4/IL-6-mediated activation of NF-κB and JAK-STAT signaling pathways.
In vitro	2,4,5-Trimethoxybenzoic acid (0-20 μg/mL, 24-72 hours) can inhibit LPS-induced IL-6 and MCP-1 secretion in J774A.1 macrophages, and reduce the expression levels of TLR4, CD36, and CD68 [1]. 2,4,5-Trimethoxybenzoic acid (0-20 μg/mL, 48 hours) not only suppresses high glucose-induced expression of HIF-1α, VEGF, TLR4, iNOS, and IL-6 in J774A.1 macrophages but also promotes the expression of anti-inflammatory factors Arg-1 and IL-10 [1].
Synonyms	Asaronic acid

Chemical Properties

Molecular Weight	212.2
Formula	C₁₀H₁₂O₅
Cas No.	490-64-2
Smiles	O=C(O)C1=CC(OC)=C(OC)C=C1OC

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (377 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7125 mL	23.5627 mL	47.1254 mL	235.6268 mL
5 mM	0.9425 mL	4.7125 mL	9.4251 mL	47.1254 mL
10 mM	0.4713 mL	2.3563 mL	4.7125 mL	23.5627 mL
20 mM	0.2356 mL	1.1781 mL	2.3563 mL	11.7813 mL
50 mM	0.0943 mL	0.4713 mL	0.9425 mL	4.7125 mL
100 mM	0.0471 mL	0.2356 mL	0.4713 mL	2.3563 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc