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Prostaglandin A2

Name: Prostaglandin A2
Brand: TargetMol
SKU: T36542
Rating: 4.5 (1 reviews)

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Catalog No. T36542Cas No. 13345-50-1

Alias Medullin

PGA2 is a naturally occurring prostaglandin in gorgonian corals where it may function in self defense. It is generally not present in mammals. PGA2 has low biological potency in most bioassays, but it does show some antiviral/antitumor activity.[1] At a 25 uM concentration, PGA2 blocks the cell cycle progression of NIH 3T3 cells at the G1 and G2/M phase .[2] It has also been shown to act as a vasodilator with natriuretic properties.[3]

Prostaglandin A2

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Catalog No. T36542Alias MedullinCas No. 13345-50-1

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Product Introduction

Bioactivity

Description

Synonyms

Medullin

Chemical Properties

Molecular Weight	334.45
Formula	C₂₀H₃₀O₄
Cas No.	13345-50-1
Smiles	C(/C=C\CCCC(O)=O)[C@@H]1[C@@H](/C=C/[C@H](CCCCC)O)C=CC1=O
Relative Density.	1.103g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMF: 75 mg/mL (224.25 mM), Sonication is recommended.

DMSO: 50 mg/mL (149.5 mM), Sonication is recommended.

Ethanol: 100 mg/mL (299 mM), Sonication is recommended.

Solution Preparation Table

DMSO/DMF/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9900 mL	14.9499 mL	29.8998 mL	149.4992 mL
5 mM	0.5980 mL	2.9900 mL	5.9800 mL	29.8998 mL
10 mM	0.2990 mL	1.4950 mL	2.9900 mL	14.9499 mL
20 mM	0.1495 mL	0.7475 mL	1.4950 mL	7.4750 mL
50 mM	0.0598 mL	0.2990 mL	0.5980 mL	2.9900 mL
100 mM	0.0299 mL	0.1495 mL	0.2990 mL	1.4950 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc