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Magnesium Lithospermate B

Name: Magnesium Lithospermate B
Brand: TargetMol
SKU: T20793
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T20793Cas No. 122021-74-3

Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.improves renal failure.

Magnesium Lithospermate B

🥰Excellent

Purity: 99.87%

Catalog No. T20793Cas No. 122021-74-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$33	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$245	In Stock	In Stock
50 mg	$396	In Stock	In Stock
100 mg	$637	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$130	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

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COA

Product Introduction

Bioactivity

Description	Magnesium Lithospermate B is a natural product activates eNOS and ameliorates endothelial dysfunction in diabetes by enhancing vasodilation in addition to reducing oxidative stress, it can protecte cardiomyocytes from ischemic injury through specific inhibition of TAB1-p38 apoptosis signaling.improves renal failure.
In vitro	magnesium lithospermate B (MLB) dose-dependently inhibited the activation of microglia and reduced neuronal apoptosis.?Western blot analysis showed that MLB decreased the expression of inflammatory cytokine TNF- and pro-apoptotic protein cleaved caspase-3.?More importantly, MLB increased the expression of SIRT1, while inhibited the acetylation of NF-B.?Furthermore, pretreatment with sirtinol (a selective inhibitor of SIRT1) reversed all the aforementioned effects of MLB after SAH[1].
In vivo	magnesium lithospermate B (MLB), a bioactive ingredient extracted from Salvia miltiorrhiza, exerts neuroprotective effects in several central nervous system insults.administration of MLB significantly attenuated brain edema and neurological deficits after SAH[1].
Animal Research	Adult male Sprague-Dawley rats were subjected to an endovascular perforation process to produce an SAH model.?MLB was administrated intraperitoneally at 30min after SAH with a dose of 25mg/kg or 50mg/kg[1].

Chemical Properties

Molecular Weight	740.9
Formula	C₃₆H₂₈MgO₁₆
Cas No.	122021-74-3
Smiles	OC1=C2C=3C(C4=O[Mg+2]5(O=C(C=CC3C=C1)OC(CC6=CC(O)=C(O)C=C6)C(=O)[O-]5)[O-]C(=O)C(CC7=CC(O)=C(O)C=C7)O4)C(O2)C8=CC(O)=C(O)C=C8
Relative Density.	no data available
Color	Yellow
Appearance	solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (134.97 mM), Sonication is recommended.

H2O: 19.23 mg/mL (25.95 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (5.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3497 mL	6.7485 mL	13.4971 mL	67.4855 mL
5 mM	0.2699 mL	1.3497 mL	2.6994 mL	13.4971 mL
10 mM	0.1350 mL	0.6749 mL	1.3497 mL	6.7485 mL
20 mM	0.0675 mL	0.3374 mL	0.6749 mL	3.3743 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0270 mL	0.1350 mL	0.2699 mL	1.3497 mL
100 mM	0.0135 mL	0.0675 mL	0.1350 mL	0.6749 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc