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Bimosiamose

Name: Bimosiamose
Brand: TargetMol
SKU: T14574
Rating: 4.5 (1 reviews)

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Catalog No. T14574Cas No. 187269-40-5

Alias TBC-1269

Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.

Bimosiamose

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Catalog No. T14574Alias TBC-1269Cas No. 187269-40-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$83	35 days	35 days
5 mg	Inquiry	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
Targets&IC50	Eselectin:88 μM, L-selectin:86 μM, P-selectin:20 μM
In vitro	Bimosiamose (TBC-1269) effectively inhibits neutrophil recruitment to inflammation sites by obstructing the initial rolling phase of recruitment, without exhibiting cytotoxic effects on neutrophils.
In vivo	Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment significantly increases survival, ameliorates neutrophil migration by 81%, and improves histologic damage scores[1]. The best overall survival rate of 70% is observed when administered 15 minutes before reperfusion, with a marked decrease in liver enzyme levels at 6 hours after reperfusion.
Synonyms	TBC-1269

Chemical Properties

Molecular Weight	862.91
Formula	C₄₆H₅₄O₁₆
Cas No.	187269-40-5
Relative Density.	1.417 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.1 M NaOH: 25 mg/mL (28.97 mM), when pH is adjusted to 10 with NaOH. Sonication is recommended.

DMSO: 125 mg/mL (144.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (3.82 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

0.1 M NaOH/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1589 mL	5.7943 mL	11.5887 mL	57.9435 mL
5 mM	0.2318 mL	1.1589 mL	2.3177 mL	11.5887 mL
10 mM	0.1159 mL	0.5794 mL	1.1589 mL	5.7943 mL
20 mM	0.0579 mL	0.2897 mL	0.5794 mL	2.8972 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0232 mL	0.1159 mL	0.2318 mL	1.1589 mL
100 mM	0.0116 mL	0.0579 mL	0.1159 mL	0.5794 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc