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6-O-Isobutyrylbritannilactone
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Catalog No. T75554Cas No. 1259933-02-2
6-O-Isobutyrylbritannilactone is a natural sesquiterpene and melanogenesis inhibitor capable of suppressing IBMX-induced melanogenesis in B16F10 cells. It modulates ERK, CREB, and PI3K/AKT pathways while reducing pigmentation in zebrafish embryos.
6-O-Isobutyrylbritannilactone
😃Good
Purity: 99.80%
Catalog No. T75554Cas No. 1259933-02-2
6-O-Isobutyrylbritannilactone is a natural sesquiterpene and melanogenesis inhibitor capable of suppressing IBMX-induced melanogenesis in B16F10 cells. It modulates ERK, CREB, and PI3K/AKT pathways while reducing pigmentation in zebrafish embryos.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $169 | - | In Stock | |
| 5 mg | $515 | - | In Stock | |
| 10 mg | $877 | - | In Stock | |
| 25 mg | $1,280 | - | In Stock | |
| 50 mg | $1,750 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.80%
Appearance:Solid
Color:White
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Product Introduction
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Storage & Solubility Information
| Description | 6-O-Isobutyrylbritannilactone is a natural sesquiterpene and melanogenesis inhibitor capable of suppressing IBMX-induced melanogenesis in B16F10 cells. It modulates ERK, CREB, and PI3K/AKT pathways while reducing pigmentation in zebrafish embryos. |
| In vitro | 6-O-Isobutyrylbritannilactone (5-100 μM, 48 hours) exhibited cytotoxicity against IBMX-stimulated B16F10 cells [1]. 6-O-Isobutyrylbritannilactone (5-30 μM, 12 hours) dose-dependently inhibited the mRNA expression levels of whitening-related genes in IBMX-stimulated B16F10 cells [1]. 6-O-Isobutyrylbritannilactone (20 μM, 1-9 hours) time-dependently suppressed the phosphorylation of ERK, AKT, and CREB [1]. |
| In vivo | 6-O-Isobutyrylbritannilactone (10-100 μM, 48 hours) can significantly reduce pigmentation in zebrafish embryos [1]. |
| Molecular Weight | 336.42 |
| Formula | C19H28O5 |
| Cas No. | 1259933-02-2 |
| Smiles | O(C(C(C)C)=O)[C@H]1[C@]2([C@@](CC(C)=C1[C@H](CCCO)C)(OC(=O)C2=C)[H])[H] |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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