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6-O-Isobutyrylbritannilactone
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Catalog No. T75554Cas No. 1259933-02-2
6-O-Isobutyrylbritannilactone is a natural sesquiterpene and melanogenesis inhibitor capable of suppressing IBMX-induced melanogenesis in B16F10 cells. It modulates ERK, CREB, and PI3K/AKT pathways while reducing pigmentation in zebrafish embryos.
6-O-Isobutyrylbritannilactone
😃Good
Purity: 99.80%
Catalog No. T75554Cas No. 1259933-02-2
6-O-Isobutyrylbritannilactone is a natural sesquiterpene and melanogenesis inhibitor capable of suppressing IBMX-induced melanogenesis in B16F10 cells. It modulates ERK, CREB, and PI3K/AKT pathways while reducing pigmentation in zebrafish embryos.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $169 | - | In Stock | |
| 5 mg | $515 | - | In Stock | |
| 10 mg | $877 | - | In Stock | |
| 25 mg | $1,280 | - | In Stock | |
| 50 mg | $1,750 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.80%
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Product Introduction
Bioactivity
Chemical Properties
| Description | 6-O-Isobutyrylbritannilactone is a natural sesquiterpene and melanogenesis inhibitor capable of suppressing IBMX-induced melanogenesis in B16F10 cells. It modulates ERK, CREB, and PI3K/AKT pathways while reducing pigmentation in zebrafish embryos. |
| In vitro | 6-O-Isobutyrylbritannilactone (5-100 μM, 48 hours) exhibited cytotoxicity against IBMX-stimulated B16F10 cells [1]. 6-O-Isobutyrylbritannilactone (5-30 μM, 12 hours) dose-dependently inhibited the mRNA expression levels of whitening-related genes in IBMX-stimulated B16F10 cells [1]. 6-O-Isobutyrylbritannilactone (20 μM, 1-9 hours) time-dependently suppressed the phosphorylation of ERK, AKT, and CREB [1]. |
| In vivo | 6-O-Isobutyrylbritannilactone (10-100 μM, 48 hours) can significantly reduce pigmentation in zebrafish embryos [1]. |
| Molecular Weight | 336.42 |
| Formula | C19H28O5 |
| Cas No. | 1259933-02-2 |
| Smiles | O(C(C(C)C)=O)[C@H]1[C@]2([C@@](CC(C)=C1[C@H](CCCO)C)(OC(=O)C2=C)[H])[H] |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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