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Liquidambaric lactone

Name: Liquidambaric lactone
Brand: TargetMol
SKU: T2S0605
Rating: 4.5 (1 reviews)

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Catalog No. T2S0605Cas No. 185051-75-6

Liquidambaric lactone, a compound isolated from Euonymus grandiflorus Wall, may exhibit inhibitory activity against HIV-1 reverse transcriptase.

Liquidambaric lactone

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Catalog No. T2S0605Cas No. 185051-75-6

Liquidambaric lactone, a compound isolated from Euonymus grandiflorus Wall, may exhibit inhibitory activity against HIV-1 reverse transcriptase.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$330	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description

Liquidambaric lactone, a compound isolated from Euonymus grandiflorus Wall, may exhibit inhibitory activity against HIV-1 reverse transcriptase.

In vitro

Among the 25 fractions obtained from the alcohol extractive of the roots of Lantana camara L.(Verbenaceae) by silica gel column chromatography,three fractions demonstrated inhibitory HIV-1 reverse transcriptase activity.Furthermore,six pentacyclic triterpenes were isolated by reduced pressure column chromatography and identified as oleanonic acid(1),Liquidambaric lactone(2),lantadene A(3),lantadene B(4),oleanolic acid(5),and 25-hydroxy-oleanolic acid(6) by spectral analysis. Compounds 2 and 6 were reported firstly in the plants of Verbenaceae family,and the structure of 6 was confirmed firstly by X-ray crystallography.

Chemical Properties

Molecular Weight	468.67
Formula	C₃₀H₄₄O₄
Cas No.	185051-75-6
Smiles	C[C@]1([C@@]2(CC[C@@]3([H])C4(C)C)C)[C@@]([C@@H](O5)[C@@H]5[C@]2([H])[C@]3(CCC4=O)C)(OC6=O)[C@@](CC(C)(C)CC7)([H])[C@]67CC1
Relative Density.	1.17 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc