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Ichorcumab (Synonyms: JNJ-9375, JNJ-64179375, JNJ-375, Ichorcumab)
Catalog No. T9901A-779 Copy Product Info
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Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.
Ichorcumab
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Catalog No. T9901A-779
Synonyms JNJ-9375, JNJ-64179375, JNJ-375, Ichorcumab
Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control.
Ichorcumab
Cas No. 2589583-20-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | Inquiry | Inquiry | Inquiry | |
| 5 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Related Conjugates and Formulations
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Chemical Properties
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| Description | Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets thrombin. It binds to exosite 1 of thrombin, inhibiting substrate binding without affecting its catalytic activity. For isotype control, refer to HumanIgG1kappa, Isotype Control. |
| In vitro | Ichorcumab (JNJ-9375) prolongs clotting time by binding to external site 1 on thrombin and inhibiting its interaction with fibrinogen and other substrates, such as factors V and VIII, as well as protease-activated receptor 1. As Ichorcumab does not affect thrombin's catalytic activity, it potentially causes less bleeding compared to anticoagulants blocking thrombin or factor Xa active sites [1]. |
| Synonyms | JNJ-9375, JNJ-64179375, JNJ-375, Ichorcumab |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Target | thrombin |
| Cas No. | 2589583-20-8 |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice. |
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