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S-Adenosyl-L-methionine iodide

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Catalog No. T74497Cas No. 3493-13-8
Alias S-Adenosyl methionine iodide, AdoMet iodide, Ademetionine iodide

S-Adenosyl-L-methionine iodide is a universal methyl donor in vivo, participating in the methylation of DNA, RNA, and proteins, playing a core role in gene regulation and cellular homeostasis.

S-Adenosyl-L-methionine iodide
Other Forms of S-Adenosyl-L-methionine iodide:

S-Adenosyl-L-methionine iodide

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Catalog No. T74497Alias S-Adenosyl methionine iodide, AdoMet iodide, Ademetionine iodideCas No. 3493-13-8
S-Adenosyl-L-methionine iodide is a universal methyl donor in vivo, participating in the methylation of DNA, RNA, and proteins, playing a core role in gene regulation and cellular homeostasis.
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Appearance:Solid
Color:Yellow
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Product Introduction

Bioactivity
Description
S-Adenosyl-L-methionine iodide is a universal methyl donor in vivo, participating in the methylation of DNA, RNA, and proteins, playing a core role in gene regulation and cellular homeostasis.
In vitro
S-Adenosyl-L-methionine iodide (300 µM) induces apoptosis and cell cycle arrest in oral squamous cell carcinoma cells by downregulating cyclins B1, E1, and D1 [4]. It also enhances the sensitivity of cancer cells to 5-FU by modulating the expression of DNA methyltransferases (DNMTs) [5].
In vivo
Oral administration of S-Adenosyl-L-methionine iodide (30 mg/kg) prevents ASD-like neurobehavioral symptoms and normalizes redox potential in mouse models [6]. It also demonstrates anti-epileptic and memory-enhancing properties by reducing oxidative stress in seizure-induced rat models [7].
SynonymsS-Adenosyl methionine iodide, AdoMet iodide, Ademetionine iodide
Chemical Properties
Molecular Weight526.35
FormulaC15H23IN6O5S
Cas No.3493-13-8
SmilesO[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](C[S+](CC[C@@H](C(O)=O)N)C)[C@H]1O.[I-]
Storage & Solubility Information
Storagekeep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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