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yGsy2p-IN-H23

Catalog No. T38674 CAS 1269190-98-8

Synonyms: yGsy2p-IN-H23

yGsy2p-IN-H23 is a potent, first-in-class inhibitor specifically designed to target yeast glycogen synthase 2 (yGsy2p). It demonstrates an IC50 value of 875 μM for human glycogen synthase 1 (hGYS1). This compound binds precisely within the uridine diphosphate glucose (UDPG) binding pocket of yGsy2p. Its utilization in research primarily focuses on studying glycogen storage diseases (GSDs).

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yGsy2p-IN-H23, CAS 1269190-98-8

Pack Size	Availability	Price/USD
2 mg	5 days	$ 95.00
5 mg	5 days	$ 177.00
1 mL * 10 mM (in DMSO)	5 days	$ 178.00

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Biological Description

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Storage & Solubility Information

Description	yGsy2p-IN-H23 is a potent, first-in-class inhibitor specifically designed to target yeast glycogen synthase 2 (yGsy2p). It demonstrates an IC50 value of 875 μM for human glycogen synthase 1 (hGYS1). This compound binds precisely within the uridine diphosphate glucose (UDPG) binding pocket of yGsy2p. Its utilization in research primarily focuses on studying glycogen storage diseases (GSDs).
Targets&IC50	GYS1 (human):875 µM (IC50)
In vitro	yGsy2p-IN-H23 (compound H23) has IC 50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 were 161 μM and 875 μM, respectively. yGsy2p-IN-H23 exhibits IC 50 values of 280 μM and 263 μM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P[1].

Synonyms	yGsy2p-IN-H23
Molecular Weight	377.488
Formula	C23H27N3O2
CAS No.	1269190-98-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.

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Keywords

yGsy2p-IN-H23 1269190-98-8 yGsy-2p-IN-H23 yGsy2p IN H23 yGsy2pINH23 inhibitor inhibit

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