Poacic Acid is a plant-derived stilbenoid exhibiting antifungal activity by localizing to the yeast cell wall and disrupting the production and assembly of β-1,3-glucan in fungal cell walls. It shows fungicidal activity against Saccharomyces cerevisiae and plasma membrane-compromised Candida albicans mutants [1].

Poacic Acid demonstrates significant growth inhibition against Saccharomyces cerevisiae at concentrations of 256 μg/mL or higher over 48 hours (0-512 μg/mL). It exhibits fungicidal properties against Candida albicans mutants lacking the ERG11 and ERG3 genes. Additionally, at 1 mM concentration over 1-42 hours, Poacic Acid increases chitin production and alters its distribution in the cell walls of Saccharomyces cerevisiae. The inhibitory effect on Saccharomyces cerevisiae at 512 μg/mL over 36 hours is reduced in the presence of additional β-glucan, chitin, or metal ions. [1]