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BMS-986020 sodium

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Catalog No. T63439Cas No. 1380650-53-2
Alias BMS986020 sodium, AM-152 sodium, AM152 sodium

BMS-986020 sodium (AM152 sodium) is a high-affinity LPA1 (Lysophosphatidic Acid Receptor 1) antagonist for investigating idiopathic pulmonary fibrosis, slowing the rate of decline in forced vital capacity (FVC) and pulmonary function. BMS-986020 inhibits bile acid and phospholipid transporters (BSEP, MRP4, MDR3), altering bile homeostasis.

BMS-986020 sodium
Other Forms of BMS-986020 sodium:
BMS-986020T40161257213-50-5
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BMS-986020 sodium

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Purity: 99.83%
Catalog No. T63439Alias BMS986020 sodium, AM-152 sodium, AM152 sodiumCas No. 1380650-53-2
BMS-986020 sodium (AM152 sodium) is a high-affinity LPA1 (Lysophosphatidic Acid Receptor 1) antagonist for investigating idiopathic pulmonary fibrosis, slowing the rate of decline in forced vital capacity (FVC) and pulmonary function. BMS-986020 inhibits bile acid and phospholipid transporters (BSEP, MRP4, MDR3), altering bile homeostasis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$34-In Stock
5 mgPreferential-In Stock
10 mgPreferential-In Stock
1 mL x 10 mM (in DMSO)$149-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.83%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
BMS-986020 sodium (AM152 sodium) is a high-affinity LPA1 (Lysophosphatidic Acid Receptor 1) antagonist for investigating idiopathic pulmonary fibrosis, slowing the rate of decline in forced vital capacity (FVC) and pulmonary function. BMS-986020 inhibits bile acid and phospholipid transporters (BSEP, MRP4, MDR3), altering bile homeostasis.
Targets&IC50
MRP4:6.2 μM, BSEP:4.8 μM, MDR3:7.5 μM
In vitro
BMS-986020 sodium can inhibit the efflux transporters of bile acids in the liver, including BSEP (half-maximal inhibitory concentration IC₅₀ of 1.8μM), MRP3 (IC₅₀ of 22μM), and MRP4 (IC₅₀ of 6.2μM). At a concentration of 10μM, it suppresses the canalicular efflux of bile acids in Homo sapiens hepatocytes (inhibition rate of 68%). When the concentration reaches ≥10μM, BMS-986020 sodium impairs mitochondrial function in both Homo sapiens hepatocytes and cholangiocytes, including basal respiration, maximal respiration, adenosine triphosphate (ATP) production, and reserve capacity. Additionally, it inhibits phospholipid efflux in Homo sapiens hepatocytes (IC₅₀ for MDR3 is 7.5μM)[1].
In vivo
BMS-986020 sodium (0.5, 2, 5, and 10 mg/kg, administered via gavage immediately or 3 hours after reperfusion) significantly reduced the cerebral infarction volume and neurological deficit scores induced by transient middle cerebral artery occlusion (tMCAO) in mice, with the most pronounced effects observed at doses of 5 and 10 mg/kg. Moreover, administration 3 hours after reperfusion provided equivalent protective efficacy[2].
SynonymsBMS986020 sodium, AM-152 sodium, AM152 sodium
Chemical Properties
Molecular Weight504.51
FormulaC29H25N2NaO5
Cas No.1380650-53-2
Smiles[O-]C(C1(C2=CC=C(C3=CC=C(C4=C(C(C)=NO4)NC(O[C@@H](C5=CC=CC=C5)C)=O)C=C3)C=C2)CC1)=O.[Na+]
Storage & Solubility Information
Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 120 mg/mL (237.85 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (9.91 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9821 mL9.9106 mL19.8212 mL99.1061 mL
5 mM0.3964 mL1.9821 mL3.9642 mL19.8212 mL
10 mM0.1982 mL0.9911 mL1.9821 mL9.9106 mL
20 mM0.0991 mL0.4955 mL0.9911 mL4.9553 mL
50 mM0.0396 mL0.1982 mL0.3964 mL1.9821 mL
100 mM0.0198 mL0.0991 mL0.1982 mL0.9911 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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