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Antiviral agent 35

Catalog No. T79567 CAS 2760972-52-7

Antiviral agent 35 (compound 4d) serves as a potent orally active inhibitor of the influenza virus, targeting early stages of viral replication. It suppresses influenza-induced ROS accumulation, autophagy, and apoptosis, along with the inflammatory response mediated by the RIG-1 pathway in a mouse model of pulmonary infection. Its cytotoxicity is minimal in MDCK cells, displaying a CC50 greater than 800 μM, and possesses anti-H1N1 (A/Weiss/43) activity with an EC50 of 2.28 μM [1].

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Antiviral agent 35, CAS 2760972-52-7

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Description	Antiviral agent 35 (compound 4d) serves as a potent orally active inhibitor of the influenza virus, targeting early stages of viral replication. It suppresses influenza-induced ROS accumulation, autophagy, and apoptosis, along with the inflammatory response mediated by the RIG-1 pathway in a mouse model of pulmonary infection. Its cytotoxicity is minimal in MDCK cells, displaying a CC50 greater than 800 μM, and possesses anti-H1N1 (A/Weiss/43) activity with an EC50 of 2.28 μM [1].
In vitro	Antiviral agent 35 (compound 4d), at concentrations of 25 μM and 50 μM over a period of 24 to 72 hours, inhibits the replication of the influenza virus in MDCK cells [1].
In vivo	Antiviral agent 35 (compound 4d), administered to mice orally via gavage at dosages of 25, 50, and 100 mg/kg/day on days 2, 4, and 6 post-H1N1 infection, reduced pulmonary inflammation [1].

Molecular Weight	418.47
Formula	C23H18N2O4S
CAS No.	2760972-52-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

Antiviral agent 35 2760972-52-7 Microbiology/Virology Influenza Virus inhibitor inhibit

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