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Margatoxin TFA

Catalog No. T80034

Margatoxin TFA, an alpha-KTx scorpion toxin isolated from Centruroides margaritatus venom, is a 39-amino-acid peptide that serves as a high-affinity inhibitor of Kv1.3 (Kd = 11.7 pM). It also inhibits Kv1.2 (Kd = 6.4 pM) and Kv1.1 (Kd = 4.2 nM), making it a valuable tool for ion channel research [1] [2].

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Margatoxin TFA, CAS N/A

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Margatoxin TFA, an alpha-KTx scorpion toxin isolated from Centruroides margaritatus venom, is a 39-amino-acid peptide that serves as a high-affinity inhibitor of Kv1.3 (Kd = 11.7 pM). It also inhibits Kv1.2 (Kd = 6.4 pM) and Kv1.1 (Kd = 4.2 nM), making it a valuable tool for ion channel research [1] [2].
In vivo	In 12-week-old C57BL/6J mice, Margatoxin TFA (ip; 1 pmol/g) significantly reduced thioglycollate-induced peritoneal leukocyte migration [2].

Molecular Weight	4178.95 (free base)
Formula	C178H286N52O50S7.xC2HF3O2

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Noxiustoxin Phrixotoxin-1 Tolbutamide Wilfordine GAL-021 BMS-191095 Tertiapin-RQ P-1075

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Margatoxin TFA Membrane transporter/Ion channel Potassium Channel inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.