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Diethyl malonate

Name: Diethyl malonate
Brand: TargetMol
SKU: T5616
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5616Cas No. 105-53-3

Diethyl malonate is naturally occurring in grapes and strawberries.

Diethyl malonate

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🥰Excellent

Purity: 99.83%

Catalog No. T5616Cas No. 105-53-3

Diethyl malonate is naturally occurring in grapes and strawberries.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Liquid

Color:Transparent

Resource Download

COA HNMR LCMS

Product Introduction

Diethyl malonate AI Summary

Diethyl malonate exhibits significant antileukemic activity against P-388 lymphocytic leukemia in BDF1 male mice, with an average survival of 11 days at a dose of 0.6 mg/kg/day when administered intraperitoneally. Notably, at a higher dose of 60 mg/kg/day, the compound achieved a T/C value of 114%, reflecting its efficacy in inhibiting leukemia cell growth in vivo. Additionally, Diethyl malonate shows potential as an alpha-glucosidase inhibitor with an IC50 value of 5000.0 nM, suggesting another possible mechanism of bioactivity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Diethyl malonate is naturally occurring in grapes and strawberries.

Chemical Properties

Molecular Weight	160.17
Formula	C₇H₁₂O₄
Cas No.	105-53-3
Smiles	CCOC(=O)CC(=O)OCC
Relative Density.	1.055

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 10 mg/mL (62.43 mM), Sonication is recommended.

DMSO: 60 mg/mL (374.6 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	6.2434 mL	31.2168 mL	62.4337 mL	312.1683 mL
5 mM	1.2487 mL	6.2434 mL	12.4867 mL	62.4337 mL
10 mM	0.6243 mL	3.1217 mL	6.2434 mL	31.2168 mL
20 mM	0.3122 mL	1.5608 mL	3.1217 mL	15.6084 mL
50 mM	0.1249 mL	0.6243 mL	1.2487 mL	6.2434 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0624 mL	0.3122 mL	0.6243 mL	3.1217 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc