Shopping Cart

Your shopping cart is currently empty

DDO-7263

Name: DDO-7263
Brand: TargetMol
SKU: T60487
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T60487Cas No. 2254004-96-9

DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 is a potent Nrf2 activator that activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity [1].

DDO-7263

🥰Excellent

Purity: 99.85%

Catalog No. T60487Cas No. 2254004-96-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$93	In Stock	In Stock
10 mg	$147	In Stock	In Stock
25 mg	$247	In Stock	In Stock
50 mg	$328	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.85%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	DDO-7263 is a 1,2,4-Oxadiazole derivative that upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 is a potent Nrf2 activator that activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity [1].
In vitro	DDO-7263 (20 μM; 2-24 h) can upregulate the protein levels of NQO1 and HO-1. DDO-7263 (2.5, 5, 10, 20, 40, 80 μM; 24 h) can upregulate the survival rate of THP-Ms and PC12 cell after treatment of 400μM H2O2 in a concentration-dependent manner. DDO-7263 has no significant decrease on cell survival rate[1].
In vivo	DDO-7263 (10-100 mg/kg/day; IP; for 10 days) ameliorates MPTP-induced behavioral abnormalities in mice, significantly reduces chemically induced dopaminergic neuron loss of tyrosine hydroxylase (TH) in the substantia nigra (SN) and striatum of the mouse brain, and inhibits inflammatory factor secretion. DDO-7263 (7, 35, 70 mg/kg; IP) has a T1/2 of 3.32 hours and a Cmax of 1.38 mg/mL in rats[1].

Chemical Properties

Molecular Weight	273.24
Formula	C₁₄H₉F₂N₃O
Cas No.	2254004-96-9
Smiles	Cc1ccc(cn1)-c1noc(n1)-c1ccc(F)c(F)c1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.1 mg/mL (58.92 mM), Sonication and heating to 60℃ are recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (5.49 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6598 mL	18.2989 mL	36.5979 mL	182.9893 mL
5 mM	0.7320 mL	3.6598 mL	7.3196 mL	36.5979 mL
10 mM	0.3660 mL	1.8299 mL	3.6598 mL	18.2989 mL
20 mM	0.1830 mL	0.9149 mL	1.8299 mL	9.1495 mL
50 mM	0.0732 mL	0.3660 mL	0.7320 mL	3.6598 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc