reactivity

GS-6201 (CVT-6883) is a selective antagonist of the adenosine A2B receptor, demonstrating high affinity and selectivity with a Ki of 22 nM for human adenosine A2B receptors.

DADPS Biotin Azide (Biotin-PEG4-amino-t-Bu-DADPS-C6-azide) is a PROTAC linker and a chemical linking unit used for constructing proteolysis-targeting chimeras, featuring favorable chemical cleavability and bioorthogonal reactivity, commonly employed in the synthesis of PROTAC molecules with targeted protein degradation functionality.

D-GsMTx4 TFA belongs to natural products and is a TRPC1/6 and Piezo2 channel inhibitor with high selectivity and cell permeability, inhibiting Ca2+ influx and the mTOR pathway. This compound is used in research on myocardial infarction, chronic pain, and pulmonary fibrosis.

Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.

Flavanone (2-Phenylchroman-4-one)s from citrus fruits have also been shown to exert beneficial effects on human vascular function. In particular, chronic interventions with orange juice, or the pure flavanone hesperidin, resulted in a decrease in blood pressure in overweight volunteers and acute improvements in microvascular reactivity.

bis(p-methoxyphenyl)iodonium bromide (Di(p-anisyl)iodonium Bromide) is a bromide salt consisting of two p-methoxyphenyl iodonium molecules linked together by a bromide ion. It has been used as a reagent in the synthesis of polymers, in the preparation of nanoparticles and in the synthesis of organic dyes. It has also been used to study the structure and reactivity of organic molecules and to study the structure and reactivity of inorganic molecules.

2,3,4-Trifluoro-5-Nitro-Benzoic Acid is a useful intermediate in organic synthesis. It has been used to study the effect of fluorine substitution on the reactivity of organic molecules. It has also been used to study the effect of nitro substitution on the reactivity of organic molecules.

2-Benzylpyridine is a reagent used in biochemical research.It combines the stability of aromatic compounds with the reactivity of ketone groups and is often used as a heterocyclic ketone model reagent in biochemical experiments.

fmoc-L-2-cyanophenylalanine is a derivative of the amino acid phenylalanine. Due to its excellent reactivity and stability, it is widely used in peptide synthesis, as well as in the synthesis of a variety of other biologically active molecules, such as peptide hormones, enzymes and antibodies.

GB-88 is an orally active, highly selective, non-peptide PAR2 antagonist that blocks downstream inflammatory and pain signaling pathways by inhibiting PAR2-mediated Ca²⁺ release (IC₅₀ = 2 μM). GB-88 exhibits antagonistic activity against various PAR2 agonists, including trypsin, SLIGRL-NH₂, and GB110, and shows no significant cross-reactivity with PAR1, PAR3, or PAR4. GB-88 is suitable for research into diseases such as inflammation, pain, and metabolic disorders.

DBCO-NHCO-PEG4-NHS ester is a DBCO-containing PEGylated active ester linker that combines NHS ester reactivity toward primary amines with strain-promoted azide-alkyne cycloaddition capability. It enables efficient bioconjugation through amide coupling and copper-free click reaction with azide groups. The PEG4 spacer provides hydrophilicity and tunable linker length, making it widely used in PROTAC and antibody-drug conjugate (ADC) construction.

IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also has the potential for the study of respiratory infection.

CIK4, an optimized cage-like electrophilic probe, significantly enhances the coverage of intracellular cysteine residues. It serves as a valuable tool for studying changes in cysteine reactivity and PTMs (post-translational modifications).

GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor, with an IC50 value of 39.31 μM for GAPDH enzyme activity. It forms a covalent adduct with the aspartic acid in the active site, displacing the enzyme's cofactor NAD+, and simultaneously enhances the reactivity of cysteine-reactive probes with the catalytic cysteine.

Pomalidomide-methylamino-PEG1-NH2 hydrochloride, acts as a building block for developing protein degraders and in PROTAC research. It comprises a Cereblon (CRBN)-recruiting ligand, a linker, and a pendant amine that facilitates reactivity with a carboxylic acid on the target ligand.

Thalidomide-5-carbaldehyde is an aldehyde-containing analogue of Thalidomide. Thalidomide recruits E3 ligase for ubiquitination, leading to proteolysis of target proteins. The aldehyde group exhibits high reactivity towards amine nucleophiles through reactions such as reductive amination.

β-CCM is a benzodiazepine receptor inverse agonist with anxiogenic and convulsant effects. It enhances emotional reactivity and reduces interference sensitivity in spatial working memory tasks. β-CCM is applicable in research related to anxiety disorders.

Carumonam, an antibiotic, could enhance the reactivity of Escherichia coli with mono- and polyclonal antisera to rough Escherichia coli J5.

Paclitaxel-2′-succinate NHS ester is a derivative of paclitaxel featuring a succinate linker with its carboxyl group activated as an NHS ester. The NHS ester moiety exhibits high reactivity towards amino or hydroxyl groups, facilitating its conjugation with various molecules (such as peptides, proteins, antibodies, enzymes, or polymers). This compound is utilized in the development of nanomedicines and cancer research.

(R)-Glycidol tosylate is an exceptionally important chiral building block. Featuring a tosylate leaving group and highly optically pure epoxide structure, it exhibits superb reactivity in regioselective nucleophilic ring-opening reactions, serving as a core raw material for synthesizing diverse chiral drugs like beta-blockers.

4-Aminophenylarsonic acid is an arsenic-containing aromatic organic compound consisting of a benzene ring, a para-amino group (-NH₂), and an arsonic acid group (-AsO(OH)₂). It exhibits antibacterial activity against colistin-susceptible Klebsiella pneumoniae. Combining the chemical properties of organic arsenic with the reactivity of amino groups, it can be used to prepare affinity chromatography resins, targeted drug carriers, and functional nanomaterials.

ACI-19278 is a TDP-43 PET tracer with an average Kd of 25 nM. It selectively binds to pathological TDP-43 aggregates without cross-reactivity to proteins such as Aβ and Tau. Using positron emission tomography ([18F]ACI-19278), this compound has successfully visualized TDP-43 pathology in the human brain. ACI-19278 is suitable for in vivo diagnostic research of TDP-43 protein pathologies.

OMJ-4 is a modulator of mutant α-mannosidase (alpha-mannosidase). It restores the catalytic function of the mutant α-mannosidase and enhances substrate binding capability by altering its compactness and active site flexibility. Acting as a substrate reactivity inducer, OMJ-4 increases the reactivity of mannose disaccharides binding to mutant α-mannosidase and lowers the activation energy required for the enzyme-catalyzed reaction. OMJ-4 is useful for research related to α-mannosidosis.

P-536 is an ACE inhibitor that concurrently inhibits the thymidine kinase of herpes simplex virus (HSV-1) and the RNA polymerase of Trypanosoma cruzi. By suppressing the renin-angiotensin system, downregulating AT1R and NOX4 expression, and decreasing oxidative stress (lowering plasma hydrogen peroxide (H2O2) and 8-isoprostane levels), P-536 effectively reduces systolic blood pressure and enhances vascular reactivity. Additionally, P-536 hinders the replication of DNA/RNA viruses such as HSV-1 by blocking nucleotide metabolism and nucleic acid synthesis; it competitively inhibits Trypanosoma cruzi RNA synthesis, suppresses epimastigote replication, and thereby obstructs their growth. P-536 is applicable in the research of hypertension, insulin resistance, and Chagas disease.