reactivity

GS-6201 (CVT-6883) is a selective antagonist of the adenosine A2B receptor, demonstrating high affinity and selectivity with a Ki of 22 nM for human adenosine A2B receptors.

D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia/reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.

Minalrestat(ARI-509) is an orally active and potent aldose reductase inhibitor for the study of impaired microvascular reactivity in diabetic patients.

Flavanone (2-Phenylchroman-4-one)s from citrus fruits have also been shown to exert beneficial effects on human vascular function. In particular, chronic interventions with orange juice, or the pure flavanone hesperidin, resulted in a decrease in blood pressure in overweight volunteers and acute improvements in microvascular reactivity.

bis(p-methoxyphenyl)iodonium bromide (Di(p-anisyl)iodonium Bromide) is a bromide salt consisting of two p-methoxyphenyl iodonium molecules linked together by a bromide ion. It has been used as a reagent in the synthesis of polymers, in the preparation of nanoparticles and in the synthesis of organic dyes. It has also been used to study the structure and reactivity of organic molecules and to study the structure and reactivity of inorganic molecules.

2,3,4-Trifluoro-5-Nitro-Benzoic Acid is a useful intermediate in organic synthesis. It has been used to study the effect of fluorine substitution on the reactivity of organic molecules. It has also been used to study the effect of nitro substitution on the reactivity of organic molecules.

2-Benzylpyridine is a reagent used in biochemical research.It combines the stability of aromatic compounds with the reactivity of ketone groups and is often used as a heterocyclic ketone model reagent in biochemical experiments.

fmoc-L-2-cyanophenylalanine is a derivative of the amino acid phenylalanine. Due to its excellent reactivity and stability, it is widely used in peptide synthesis, as well as in the synthesis of a variety of other biologically active molecules, such as peptide hormones, enzymes and antibodies.

IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also has the potential for the study of respiratory infection.

GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor, with an IC50 value of 39.31 μM for GAPDH enzyme activity. It forms a covalent adduct with the aspartic acid in the active site, displacing the enzyme's cofactor NAD+, and simultaneously enhances the reactivity of cysteine-reactive probes with the catalytic cysteine.

Pomalidomide-methylamino-PEG1-NH2 hydrochloride, acts as a building block for developing protein degraders and in PROTAC research. It comprises a Cereblon (CRBN)-recruiting ligand, a linker, and a pendant amine that facilitates reactivity with a carboxylic acid on the target ligand.

Thalidomide-5-carbaldehyde is an aldehyde-containing analogue of Thalidomide. Thalidomide recruits E3 ligase for ubiquitination, leading to proteolysis of target proteins. The aldehyde group exhibits high reactivity towards amine nucleophiles through reactions such as reductive amination.

β-CCM is a benzodiazepine receptor inverse agonist with anxiogenic and convulsant effects. It enhances emotional reactivity and reduces interference sensitivity in spatial working memory tasks. β-CCM is applicable in research related to anxiety disorders.

Carumonam, an antibiotic, could enhance the reactivity of Escherichia coli with mono- and polyclonal antisera to rough Escherichia coli J5.

Paclitaxel-2′-succinate NHS ester is a derivative of paclitaxel featuring a succinate linker with its carboxyl group activated as an NHS ester. The NHS ester moiety exhibits high reactivity towards amino or hydroxyl groups, facilitating its conjugation with various molecules (such as peptides, proteins, antibodies, enzymes, or polymers). This compound is utilized in the development of nanomedicines and cancer research.

Divinyl ketone is a kind of high reactivity, easy polymerization of multifunctional cyclization reagent.

2-Amino-5-bromo-6-chloropyrazine is a heterocyclic building block.1,2It has been used in the synthesis of Akt inhibitors. 1.Kettle, J.G., Brown, S., Crafter, C., et al.Diverse heterocyclic scaffolds as allosteric inhibitors of AKTJ. Med. Chem.55(3)1261-1273(2012) 2.Goel, R., Luxami, V., and Paul, K.Recent advances in development of imidazo[1,2-a]pyrazines: Synthesis, reactivity and their biological applicationsOrg. Biomol. Chem.13(12)3525-3555(2015)

N-methyl-2-HOBA is a methylated form of the isoketal scavenger 2-HOBA .1It has low reactivity with isoketals and has no effect on hypertension induced by angiotensin II . N-methyl-2-HOBA has been used as a negative control for the activity of 2-HOBA in a mouse model of hypertension. 1.Kirabo, A., Fontana, V., de Faria, A.P.C., et al.DC isoketal-modified proteins activate T cells and promote hypertensionJ. Clin. Invest.124(10)4642-4656(2014)

CE3F4 analog 1 is an analogue of CE3F4. It is a chemical compound utilized in various [scientific applications] due to its unique properties, notably in (radical scavenging) and (oxidation-reduction) processes. It plays a significant role in advanced (catalysis), (pharmaceutical) research, and (material science) due to its stability and reactivity.

8-Azido-ATP is a nucleotide analog that demonstrates photo-reactivity properties. It offers utility in the precise labeling and identification of proteins, particularly those involved in DNA-dependent RNA polymerase activity.

ONX-0914 (PR-957) is a potent and highly specific immunoproteasome inhibitor with minimal cross-reactivity to the constitutive proteasome.

CCW16 is a covalent E3 ubiquitin ligase RNF4 ligand exhibiting cysteine reactivity, capable of inducing ferroptosis in AML cells by activating ROS signalling. CCW16 may be utilised in synthesising PROTAC degraders such as CCW 28-3.

LASSBio-1632 is a novel anti-asthmatic lead candidate that selectively inhibits PDE4A and PDE4D isoenzymes, leading to the suppression of airway hyper-reactivity (AHR) and TNF-α production in lung tissue. With high experimental BBB permeability, LASSBio-1632 (7j) efficiently crosses the blood-brain barrier through passive diffusion [1].

WT IDH1 Inhibitor 2 is a wild-type isocitrate dehydrogenase 1 (WT IDH1) inhibitor (IC50: 120 nM) and is a mutant R132H IDH1 inhibitor, an isoform of GSK321 with wild-type cross-reactivity.