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Anti-LMNA Monoclonal Antibody (5B815)

(Synonyms: PRO1, LMNL1, LMNC, LMN1, LFP, LDP1, IDC, HGPS, FPLD2, FPLD, FPL, EMD2, CMT2B1, CMD1A, CDDC, CDCD1) Copy Product Info
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Synonyms: PRO1, LMNL1, LMNC, LMN1, LFP, LDP1, IDC, HGPS, FPLD2, FPLD, FPL, EMD2, CMT2B1, CMD1A, CDDC, CDCD1

Catalog No. TMAT-0659 Copy Product Info
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Anti-LMNA Monoclonal Antibody (5B815) is a Mouse antibody targeting LMNA. Anti-LMNA Monoclonal Antibody (5B815) can be used in WB,IHC.

Anti-LMNA Monoclonal Antibody
(5B815)

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Product Introduction

Bioactivity
Description
Anti-LMNA Monoclonal Antibody (5B815) is a Mouse antibody targeting LMNA. Anti-LMNA Monoclonal Antibody (5B815) can be used in WB,IHC.
SynonymsPRO1, LMNL1, LMNC, LMN1, LFP, LDP1, IDC, HGPS, FPLD2, FPLD, FPL, EMD2, CMT2B1, CMD1A, CDDC, CDCD1
Ig Type
IgG1
Clone
5B815
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1/500-1/2000; IHC: 1/200-1/1000
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationPurified by protein A or protein G
AppearanceLiquid
FormulationAscitic fluid containing 0.03% sodium azide.
Concentration1 mg/mL
Research BackgroundThe nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Purified recombinant fragment of human LMNA expressed in E. Coli.
Antigen Species
Human
Gene Name
LMNA
Gene ID
Protein Name
Prelamin-A/C
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 74 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: Anti-LMNA Monoclonal Antibody (5B815) molecular weight