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Anti-CK17 Monoclonal Antibody (8U310)
(Synonyms: PCHC1, PC2, PC, KRT17, K17) Copy Product Info
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Synonyms: PCHC1, PC2, PC, KRT17, K17
Catalog No. TMAT-1216 Copy Product Info
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Anti-CK17 Monoclonal Antibody (8U310) is a Mouse antibody targeting CK17. Anti-CK17 Monoclonal Antibody (8U310) can be used in WB,IHC.
Anti-CK17 Monoclonal Antibody
(8U310)
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Product Introduction
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| Description | Anti-CK17 Monoclonal Antibody (8U310) is a Mouse antibody targeting CK17. Anti-CK17 Monoclonal Antibody (8U310) can be used in WB,IHC. |
| Synonyms | PCHC1, PC2, PC, KRT17, K17 |
| Ig Type | IgG2b |
| Clone | 8U310 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | CK17, also known as KRT17, it is the type I intermediate filament chain keratin 17. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of CK17 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | KRT17 |
| Gene ID | |
| Protein Name | Keratin, type I cytoskeletal 17 |
| Uniprot ID |
| Molecular Weight | Theoretical: 49 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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