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Anti-NGFR Monoclonal Antibody (9G794)
(Synonyms: TNFRSF16, p75NTR, p75(NTR), NGFR, Gp80-LNGFR, CD271) Copy Product Info
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Synonyms: TNFRSF16, p75NTR, p75(NTR), NGFR, Gp80-LNGFR, CD271
Catalog No. TMAT-0750 Copy Product Info
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Anti-NGFR Monoclonal Antibody (9G794) is a Mouse antibody targeting NGFR. Anti-NGFR Monoclonal Antibody (9G794) can be used in IF,FCM.
Anti-NGFR Monoclonal Antibody
(9G794)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Stability & Storage
| Description | Anti-NGFR Monoclonal Antibody (9G794) is a Mouse antibody targeting NGFR. Anti-NGFR Monoclonal Antibody (9G794) can be used in IF,FCM. |
| Synonyms | TNFRSF16, p75NTR, p75(NTR), NGFR, Gp80-LNGFR, CD271 |
| Ig Type | IgG1 |
| Clone | 9G794 |
| Reactivity | Human |
| Application | |
| Recommended Dose | IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells). |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human NGFR expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | NGFR |
| Gene ID | |
| Protein Name | Tumor necrosis factor receptor superfamily member 16 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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