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Anti-GSK3A Monoclonal Antibody (6L466)
(Synonyms: GSK3 alpha, DKFZp686D0638) Copy Product Info
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Synonyms: GSK3 alpha, DKFZp686D0638
Catalog No. TMAT-1080 Copy Product Info
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Anti-GSK3A Monoclonal Antibody (6L466) is a Mouse antibody targeting GSK3A. Anti-GSK3A Monoclonal Antibody (6L466) can be used in WB,IF.
Anti-GSK3A Monoclonal Antibody
(6L466)
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| Description | Anti-GSK3A Monoclonal Antibody (6L466) is a Mouse antibody targeting GSK3A. Anti-GSK3A Monoclonal Antibody (6L466) can be used in WB,IF. |
| Synonyms | GSK3 alpha, DKFZp686D0638 |
| Ig Type | IgG1 |
| Clone | 6L466 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IF: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | Glycogen synthase kinase 3 alpha belongs to the Ser/Thr family of protein kinases, Cdc2/cdkx subfamily; GSK3 subsubfamily. It is implicated in the hormonal control of several regulatory proteins including glycogen synthase, myb, and the transcription factor c jun. GSK3 phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK3 and subsequently inhibits GSK3 acutely leading to the stimulation of glycogen synthesis. GSK3 signaling is performed by two isoforms, GSK3 alpha and GSK3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of GSK3 alpha expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | GSK3A |
| Gene ID | |
| Protein Name | Glycogen synthase kinase-3 alpha |
| Uniprot ID |
| Molecular Weight | Theoretical: 51 kDa |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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