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Anti-PROZ Monoclonal Antibody (8L93)
(Synonyms: PZ, protein Z) Copy Product Info
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Synonyms: PZ, protein Z
Catalog No. TMAT-0924 Copy Product Info
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Anti-PROZ Monoclonal Antibody (8L93) is a Mouse antibody targeting PROZ. Anti-PROZ Monoclonal Antibody (8L93) can be used in WB.
Anti-PROZ Monoclonal Antibody
(8L93)
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Product Introduction
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Related Conjugates and Formulations
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| Description | Anti-PROZ Monoclonal Antibody (8L93) is a Mouse antibody targeting PROZ. Anti-PROZ Monoclonal Antibody (8L93) can be used in WB. |
| Synonyms | PZ, protein Z |
| Ig Type | IgG1 |
| Clone | 8L93 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency; there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of PROZ expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | PROZ |
| Gene ID | |
| Protein Name | Vitamin K-dependent protein Z |
| Uniprot ID |
| Molecular Weight | Theoretical: 45 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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