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Anti-TOP2A Monoclonal Antibody (3S466)
(Synonyms: TP2A, TOP2) Copy Product Info
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Synonyms: TP2A, TOP2
Catalog No. TMAT-0812 Copy Product Info
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Anti-TOP2A Monoclonal Antibody (3S466) is a Mouse antibody targeting TOP2A. Anti-TOP2A Monoclonal Antibody (3S466) can be used in WB,IF,FCM.
Anti-TOP2A Monoclonal Antibody
(3S466)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-TOP2A Monoclonal Antibody (3S466) is a Mouse antibody targeting TOP2A. Anti-TOP2A Monoclonal Antibody (3S466) can be used in WB,IF,FCM. |
| Synonyms | TP2A, TOP2 |
| Ig Type | IgG2b |
| Clone | 3S466 |
| Reactivity | Human,Rat |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IF: 1/100-1/500; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human TOP2A (AA: 1100-1530) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | TOP2A |
| Gene ID | |
| Protein Name | DNA topoisomerase 2-alpha |
| Uniprot ID |
| Molecular Weight | Theoretical: 174.4 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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