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Anti-LYN Monoclonal Antibody (4S766)
(Synonyms: JTK8, FLJ26625) Copy Product Info
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Synonyms: JTK8, FLJ26625
Catalog No. TMAT-0743 Copy Product Info
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Anti-LYN Monoclonal Antibody (4S766) is a Mouse antibody targeting LYN. Anti-LYN Monoclonal Antibody (4S766) can be used in WB.
Anti-LYN Monoclonal Antibody
(4S766)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Stability & Storage
| Description | Anti-LYN Monoclonal Antibody (4S766) is a Mouse antibody targeting LYN. Anti-LYN Monoclonal Antibody (4S766) can be used in WB. |
| Synonyms | JTK8, FLJ26625 |
| Ig Type | IgG2b |
| Clone | 4S766 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | Lyn (also known as p53/56 Lyn) is a membrane-associated protein tyrosine kinase (PTK) mostly expressed in hemopoietic cells which is important in cellular signaling. It contains an SH2 and SH3 domain and has been found to be cleaved after activation of caspases in apoptosis. A member of the Src family of PTKs, there are two known isoforms for Lyn which plays an indispensable role in the Fc epsilon RI (Fcer1) and the B-cell IgM receptor signaling pathway and is essential for Syk activation and Lat phosphorylation after Fcer1 aggregation and can also phosphor-ylate Tec on multiple residues. Lyn can also be regulated by IL-2 and IL-3.Lyn is a member of the src family of non-receptor protein tyrosine kinases that is predominantly expressed in haematopoietic tissues. Like all members of the src family, lyn is thought to participate in signal transduction from cell surface receptors that lack intrinsic tyrosine kinase activity. It is associated with a number of cell surface receptors including the B cell antigen receptor and immunoglobulin E receptor (FceRI). |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of LYN expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | LYN |
| Gene ID | |
| Protein Name | Tyrosine-protein kinase Lyn |
| Uniprot ID |
| Molecular Weight | Theoretical: 56 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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