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Anti-RPA1 Monoclonal Antibody (5L459)
(Synonyms: RPA70, RP-A, RF-A, REPA1, PFBMFT6, MST075, HSSB) Copy Product Info
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Synonyms: RPA70, RP-A, RF-A, REPA1, PFBMFT6, MST075, HSSB
Catalog No. TMAT-0955 Copy Product Info
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Anti-RPA1 Monoclonal Antibody (5L459) is a Mouse antibody targeting RPA1. Anti-RPA1 Monoclonal Antibody (5L459) can be used in WB,IHC,IF,FCM.
Anti-RPA1 Monoclonal Antibody
(5L459)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Stability & Storage
| Description | Anti-RPA1 Monoclonal Antibody (5L459) is a Mouse antibody targeting RPA1. Anti-RPA1 Monoclonal Antibody (5L459) can be used in WB,IHC,IF,FCM. |
| Synonyms | RPA70, RP-A, RF-A, REPA1, PFBMFT6, MST075, HSSB |
| Ig Type | IgG1 |
| Clone | 5L459 |
| Reactivity | Human,Monkey |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000; IF: 1/200-1/1000; FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide |
| Concentration | 1 mg/mL |
| Research Background | This gene encodes the largest subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The nucleoprotein complex protects the single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. This subunit contains four oligonucleotide/oligosaccharide-binding (OB) domains, though the majority of ssDNA binding occurs in two of these domains. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which ssDNA binding domains are utilized. The different binding modes differ in the length of DNA bound and in the proteins with which it interacts, thereby playing a role in regulating different genomic maintenance pathways. [provided by RefSeq, Sep 2017] |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human RPA1 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | RPA1 |
| Gene ID | |
| Protein Name | Replication protein A 70 kDa DNA-binding subunit |
| Uniprot ID |
| Molecular Weight | Theoretical: 68.1 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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