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Anti-TP53 Monoclonal Antibody (1Y943)
(Synonyms: TRP53, P53, LFS1, BMFS5, BCC7) Copy Product Info
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Synonyms: TRP53, P53, LFS1, BMFS5, BCC7
Catalog No. TMAT-0691 Copy Product Info
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Anti-TP53 Monoclonal Antibody (1Y943) is a Mouse antibody targeting TP53. Anti-TP53 Monoclonal Antibody (1Y943) can be used in WB,IHC.
Anti-TP53 Monoclonal Antibody
(1Y943)
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| Description | Anti-TP53 Monoclonal Antibody (1Y943) is a Mouse antibody targeting TP53. Anti-TP53 Monoclonal Antibody (1Y943) can be used in WB,IHC. |
| Synonyms | TRP53, P53, LFS1, BMFS5, BCC7 |
| Ig Type | IgG1 |
| Clone | 1Y943 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB: 1/500-1/2000; IHC: 1/200-1/1000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human p53 expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | TP53 |
| Gene ID | |
| Protein Name | Cellular tumor antigen p53 |
| Uniprot ID |
| Molecular Weight | Theoretical: 43.7 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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