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Anti-RBL2 Monoclonal Antibody (6H959)
(Synonyms: Rb2, P130) Copy Product Info
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Synonyms: Rb2, P130
Catalog No. TMAT-1249 Copy Product Info
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Anti-RBL2 Monoclonal Antibody (6H959) is a Mouse antibody targeting RBL2. Anti-RBL2 Monoclonal Antibody (6H959) can be used in FCM.
Anti-RBL2 Monoclonal Antibody
(6H959)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Stability & Storage
| Description | Anti-RBL2 Monoclonal Antibody (6H959) is a Mouse antibody targeting RBL2. Anti-RBL2 Monoclonal Antibody (6H959) can be used in FCM. |
| Synonyms | Rb2, P130 |
| Ig Type | IgG1 |
| Clone | 6H959 |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM: 1/200-1/400 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | Hybridoma Monoclonal Antibody |
| Purification | Purified by protein A or protein G |
| Appearance | Liquid |
| Formulation | PBS with 0.05% sodium azide. |
| Concentration | 1 mg/mL |
| Research Background | RBL2 is a Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. |
| Conjucates | Unconjugated |
| Immunogen | Purified recombinant fragment of human RBL2 (AA: 939-1139) expressed in E. Coli. |
| Antigen Species | Human |
| Gene Name | RBL2 |
| Gene ID | |
| Protein Name | Retinoblastoma-like protein 2 |
| Uniprot ID |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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